Interleukin-27: Biological Properties and Clinical Application
Jankowski, Marek.
Interleukin-27: Biological Properties and Clinical Application [electronic resource] / by Marek Jankowski, Tomasz Wandtke. - VI, 86 p. 5 illus. in color. online resource. - SpringerBriefs in Immunology, 2194-2773 . - SpringerBriefs in Immunology, .
IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.
This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
9783319396644
10.1007/978-3-319-39664-4 doi
Medicine.
Immunology.
Cytokines.
Growth factors.
Biomedicine.
Immunology.
Cytokines and Growth Factors.
Electronic books.
QR180-189.5
616.079
Interleukin-27: Biological Properties and Clinical Application [electronic resource] / by Marek Jankowski, Tomasz Wandtke. - VI, 86 p. 5 illus. in color. online resource. - SpringerBriefs in Immunology, 2194-2773 . - SpringerBriefs in Immunology, .
IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.
This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
9783319396644
10.1007/978-3-319-39664-4 doi
Medicine.
Immunology.
Cytokines.
Growth factors.
Biomedicine.
Immunology.
Cytokines and Growth Factors.
Electronic books.
QR180-189.5
616.079