The Orexin/Hypocretin System (Record no. 244228)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04922nam a22004815i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-59259-950-9 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20160614135126.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100301s2005 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781592599509 |
| -- | 978-1-59259-950-9 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1385/1592599508 |
| Source of number or code | doi |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Alfaisal Main Library |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC321-580 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PSAN |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED057000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612.8 |
| Edition number | 23 |
| 245 14 - TITLE STATEMENT | |
| Title | The Orexin/Hypocretin System |
| Medium | [electronic resource] : |
| Remainder of title | Physiology and Pathophysiology / |
| Statement of responsibility, etc | edited by Seiji Nishino, Takeshi Sakurai. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE STATEMENTS | |
| Place of production, publication, distribution, manufacture | Totowa, NJ : |
| Name of producer, publisher, distributor, manufacturer | Humana Press, |
| Date of production, publication, distribution, manufacture | 2005. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content Type Term | text |
| Content Type Code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media Type Term | computer |
| Media Type Code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier Type Term | online resource |
| Carrier Type Code | cr |
| Source | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Contemporary Clinical Neuroscience |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | History -- History and Overview of Orexin/Hypocretin Research -- Overview of the Orexin/Hypocretin Neuronal System -- Orexin and Orexin Receptors -- Orexin Projections and Localization of Orexin Receptors -- Neuronal Responses to Hypocretin/Orexin -- Afferent System of Orexin Neurons -- Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids -- Hypocretin Measurements in the CSF, and Blood and Brain Tissue -- Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTP?S Autoradiography -- Physiology -- Orexin System and Feeding Behavior -- Orexins and the Autonomic Nervous System -- Neuroendocrine Role of the Orexins (Hypocretins) -- The Orexin/Hypocretin System and Stress and Emotion -- Physiology -- Hypocretin as a Wakefulness Regulatory Peptide -- Hypocretin/Orexin Tonus and Vigilance Control -- Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance -- Orexin and Hypothalamic Control of Sleep and Waking -- Hypocretin/Orexin and Motor Function -- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency -- Overview of Human Narcolepsy -- Canine Models of Narcolepsy -- Rodent Models of Human Narcolepsy-Cataplexy -- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency -- Hypocretin Deficiency in Human Narcolepsy -- Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy -- Hypocretin Measures in Psychiatric Disorders -- Neuroendocrinology of Human Narcolepsy -- Narcolepsy and Autoimmunity -- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency -- Pharmacology of Hypocretin/Orexin Peptides and Small Molecules -- Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides -- Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurosciences. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurosciences. |
| 655 #7 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| Source of term | local |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nishino, Seiji. |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sakurai, Takeshi. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9781588294449 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Contemporary Clinical Neuroscience |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1385/1592599508">http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1385/1592599508</a> |
| 912 ## - | |
| -- | ZDB-2-SBL |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Library of Congress Classification |
| Koha item type | eBooks |
No items available.