Cancer Drug Resistance (Record no. 247355)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04834nam a22004695i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-59745-035-5 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20160614135353.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100301s2006 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781597450355 |
| -- | 978-1-59745-035-5 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-59745-035-5 |
| Source of number or code | doi |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Alfaisal Main Library |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC254-282 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCL |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED062000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.994 |
| Edition number | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Cancer Drug Resistance |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Beverly A. Teicher. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE STATEMENTS | |
| Place of production, publication, distribution, manufacture | Totowa, NJ : |
| Name of producer, publisher, distributor, manufacturer | Humana Press, |
| Date of production, publication, distribution, manufacture | 2006. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XVI, 617 p. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content Type Term | text |
| Content Type Code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media Type Term | computer |
| Media Type Code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier Type Term | online resource |
| Carrier Type Code | cr |
| Source | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Cancer Drug Discovery and Development |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Physiological Resistance -- The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors -- Influence of Tumor pH on Therapeutic Response -- Tumor Oxygenation and Treatment Response -- Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance -- PET Imaging of Response and Resistance to Cancer Therapy -- Biological Resistance -- Cancer Stem Cells Implications for Development of More Effective Therapies -- Therapeutic Resistance in Leukemia -- Tumor Site Implantation and Animal Model Selection in Oncology -- In Vivo Resistance -- Characteristics of the Metastatic Phenotype -- The Microenvironment and Drug Resistance -- Biochemical Resistance -- Glutathione and Glutathione S-Transferases in Drug Resistance -- Metallothioneins in Drug Resistance -- Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors -- New and Revised Concepts in Multidrug Resistance -- Cisplatin Resistance -- Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters -- Resistance To Taxanes -- CpG Island Methylation and Drug Resistance -- De Novo and Acquired Resistance to Antitumor Alkylating Agents -- Resistance to Antiangiogenic Agents -- The Role of Hormones, Growth Factors, and Oncogenes -- Resistance to Antiestrogens -- Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma -- Herceptin Resistance -- Role of TGF-? in Tumor Progression and Metastasis -- p53-Based Immunotherapy of Cancer -- Response and Resistance to Ionizing Radiation -- Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance -- Clinical Aspects of Resistance -- Cancer Chemotherapy -- Molecular Profiling in Breast Cancer -- Tumor Immune Escape Mechanisms. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | As genomic techniques gradually reveal the ability of malignant cells to respond to chemical and biological insults with remarkable flexibility of phenotype, it becomes clear that much remains to be done to control and eliminate such cells. In Cancer Drug Resistance, leading scientists from the best academic institutions and industrial laboratories summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to a wide variety of anticancer therapeutics, as well as suggest new approaches to the biology of drug resistance that may afford new therapeutic opportunities. The authors review physiological resistance based tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin®. Authoritative and insightful, Cancer Drug Resistance offers basic and clinical investigators a state-of-the-art synthesis of the many faceted research now available on the biology and genetics of tumor resistance, as well as exciting new approaches to its prevention and eradication. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine & Public Health. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 655 #7 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| Source of term | local |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Teicher, Beverly A. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9781588295309 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Cancer Drug Discovery and Development |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-59745-035-5">http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-59745-035-5</a> |
| 912 ## - | |
| -- | ZDB-2-SME |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Library of Congress Classification |
| Koha item type | eBooks |
No items available.