Diverse Roles of Integrin Receptors in Articular Cartilage (Record no. 255494)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04079nam a22004815i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-540-78771-6 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20160614140222.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100301s2008 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783540787716 |
| -- | 978-3-540-78771-6 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-3-540-78771-6 |
| Source of number or code | doi |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Alfaisal Main Library |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | R-RZ |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED000000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shakibaei, Mehdi. |
| Relator term | author. |
| 245 10 - TITLE STATEMENT | |
| Title | Diverse Roles of Integrin Receptors in Articular Cartilage |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | by Mehdi Shakibaei, Constanze Csaki, Ali Mobasheri. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE STATEMENTS | |
| Place of production, publication, distribution, manufacture | Berlin, Heidelberg : |
| Name of producer, publisher, distributor, manufacturer | Springer Berlin Heidelberg, |
| Date of production, publication, distribution, manufacture | 2008. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | VII, 62 p. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content Type Term | text |
| Content Type Code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media Type Term | computer |
| Media Type Code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier Type Term | online resource |
| Carrier Type Code | cr |
| Source | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Advances in Anatomy Embryology and Cell Biology, |
| International Standard Serial Number | 0301-5556 ; |
| Volume number/sequential designation | 197 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Introduction -- Integrins - multifunctional adhesion molecules -- Integrin structure-function relationships -- Structure of integrins -- EGF domains in ß1-integrins -- Integrins in articular cartilage -- Monolayer cultures -- High density (organoid-) cultures -- Concluding remarks -- Acknowledgements -- References -- Subject index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Integrins belong to an evolutionary conserved family of adhesion molecules with important biological functions throughout the animal kingdom. They are heterodimeric glycoproteins involved in cell-cell and cell-matrix adhesion and communication. Physiologically they function as intra- and extracellular signalling molecules in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic spread of tumor cells. Integrin beta 1 (ß1-integrin) is a multi-functional member of the integrin superfamily and is an integral protein involved in cell-matrix adhesion, cell signalling, cellular defense, cell adhesion, protein binding, protein heterodimerization and receptor-mediated activity. The ß1-integrin family of cell surface receptors appears to play a major role in mediating cell-extracellular matrix interactions that are important in regulating these fundamental processes. ß1-integrins are important adhesion molecules that are highly expressed in articular chondrocytes where they bind to extracellular matrix molecules including fibronectin, laminin, and fibrillar collagens. In addition to mediating cell adhesion, members of the ß1 subfamily of integrins contribute to the organisation of the cytoskeleton and activate numerous intracellular signal transduction pathways. Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine general. |
| 655 #7 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| Source of term | local |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Csaki, Constanze. |
| Relator term | author. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mobasheri, Ali. |
| Relator term | author. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9783540787709 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Advances in Anatomy Embryology and Cell Biology, |
| -- | 0301-5556 ; |
| Volume number/sequential designation | 197 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-78771-6">http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-78771-6</a> |
| 912 ## - | |
| -- | ZDB-2-SBL |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Library of Congress Classification |
| Koha item type | eBooks |
No items available.