Cyclin-Dependent Kinase (CDK) Inhibitors (Record no. 257233)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04130nam a22005055i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-4939-2926-9 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20160615101053.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150731s2016 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781493929269 |
| -- | 978-1-4939-2926-9 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-4939-2926-9 |
| Source of number or code | doi |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Alfaisal Main Library |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RM1-950 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MMG |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED071000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615 |
| Edition number | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Cyclin-Dependent Kinase (CDK) Inhibitors |
| Medium | [electronic resource] : |
| Remainder of title | Methods and Protocols / |
| Statement of responsibility, etc | edited by Mar Orzáez, Mónica Sancho Medina, Enrique Pérez-Payá. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2016. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE STATEMENTS | |
| Place of production, publication, distribution, manufacture | New York, NY : |
| Name of producer, publisher, distributor, manufacturer | Springer New York : |
| -- | Imprint: Humana Press, |
| Date of production, publication, distribution, manufacture | 2016. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | X, 227 p. 42 illus., 22 illus. in color. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content Type Term | text |
| Content Type Code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media Type Term | computer |
| Media Type Code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier Type Term | online resource |
| Carrier Type Code | cr |
| Source | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Methods in Molecular Biology, |
| International Standard Serial Number | 1064-3745 ; |
| Volume number/sequential designation | 1336 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Immunoprecipitation of CDK-Cyclin Complexes for Determination of Kinase Activity -- Expression and Purification of Recombinant Cyclins and CDKs for Activity Evaluation -- Expression and Purification of Recombinant CDKs: CDK7, CDK8 and CDK9 -- Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination -- Fragment-Based De Novo Design of Cyclin-Dependent Kinase 2 Inhibitors -- Protein-Protein Interaction Inspire the De Novo Design of Cyclin-Dependent Kinases Peptide Inhibitors -- Identification of Cyclin A Binders with a Fluorescent Peptide Sensor -- Cell Synchronization Techniques to Study the Action of CDK Inhibitors -- Analysis of CDK Inhibitors Action on Mitochondria-Mediated Apoptosis -- Evaluating the Effects of CDK Inhibitors in Ischemia-Reperfusion Injury Models -- Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair -- Drug Delivery Strategies of Chemical CDK Inhibitors -- Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs -- Evaluating Chemical CDK Inhibitors as Cell Death Inducers -- Models for the Study of the Crosstalk between Inflammation and Cell Cycle -- Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describes elaborate procedures to evaluate activity and mechanism of action of new and already identified CDK inhibitors. The third part of the book talks about protocols to evaluate metabolomics changes associated to inhibitor treatment. Drug delivery strategies focused on nanoparticle development to provide alternative internalization systems for increasing inhibitor efficacy are also described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Cyclin-Dependent Kinase (CDK) Inhibitors: Methods and Protocols is a useful tool for scientists interested in this research field. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmacology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmacology/Toxicology. |
| 655 #7 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| Source of term | local |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Orzáez, Mar. |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sancho Medina, Mónica. |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pérez-Payá, Enrique. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9781493929252 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Methods in Molecular Biology, |
| -- | 1064-3745 ; |
| Volume number/sequential designation | 1336 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-4939-2926-9">http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-1-4939-2926-9</a> |
| 912 ## - | |
| -- | ZDB-2-PRO |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Library of Congress Classification |
| Koha item type | eBooks |
No items available.