CRISPR in animals and animal models / (Record no. 542761)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05687cam a2200577Ii 4500 |
| 001 - CONTROL NUMBER | |
| control field | on1011496900 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20180529120015.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171114s2017 enk o 000 0 eng d |
| 019 ## - | |
| -- | 1011681669 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780128125076 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0128125071 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 9780128125069 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 0128125063 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)1011496900 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | DLC |
| Language of cataloging | eng |
| Transcribing agency | DLC |
| Modifying agency | AU |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Alfaisal Main Library |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QH442 |
| Item number | .C9329 2017eb |
| 245 00 - TITLE STATEMENT | |
| Title | CRISPR in animals and animal models / |
| Statement of responsibility, etc | edited by Raúl Torres-Ruiz, Sandra Rodriguez-Perales. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE STATEMENTS | |
| Place of production, publication, distribution, manufacture | London : |
| Name of producer, publisher, distributor, manufacturer | Academic Press, an imprint of Elsevier, |
| Date of production, publication, distribution, manufacture | 2017. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc | 2017. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource. |
| 336 ## - CONTENT TYPE | |
| Content Type Term | text |
| Content Type Code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media Type Term | computer |
| Media Type Code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier Type Term | online resource |
| Carrier Type Code | cr |
| Source | rdacarrier |
| 490 1# - SERIES STATEMENT | |
| Series statement | Progress in molecular biology and translational science ; |
| Volume number/sequential designation | volume 152 |
| 588 0# - | |
| -- | Online resource; title from PDF title page (EBSCO, viewed November 14, 2017) |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""Cover""; ""Title page ""; ""Copyright""; ""Contents""; ""Contributors""; ""Chapter One -- CRISPR History: Discovery, Characterization, and Prosperity""; ""Abstract""; ""1 Introduction""; ""2 Discovery of CRISPR-Cas systems""; ""2.1 Identification of CRISPR Loci and cas Genes""; ""2.2 Prediction of Small RNA-Based Antiviral Functions of CRISPR""; ""2.2.1 Identification of CRISPR-Related Small RNAs""; ""2.2.2 Origin of Spacers in CRISPR Loci""; ""2.3 Experimental Demonstration of the Basic Mechanism of CRISPR-Cas System""; ""2.3.1 Adaptation""; ""2.3.2 crRNA Biogenesis"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""2.3.3 Interference""""3 Molecular mechanisms of nucleic acid interference""; ""3.1 PAM-Dependent DNA Interference by Type I CRISPR-Cas Systems""; ""3.2 Type II CRISPR-Cas System Requires a Unique tracrRNA for DNA Interference""; ""3.3 RNA-Activated DNA Interference by Type III CRISPR-Cas Systems""; ""4 Discovery of anti-CRISPR system""; ""5 Identification of novel CRISPR-Cas systems""; ""6 Blooming of CRISPR technology""; ""References""; ""Chapter Two -- CRISPR/Cas9 Technology: Applications and Human Disease Modeling""; ""Abstract""; ""1 Genome engineering tools"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""1.1 Genome Engineering Technologies""""1.1.1 Homologous Recombination (HR)""; ""1.1.2 Double-Strand Breaks (DSBs)""; ""1.1.3 NHEJ Versus HDR""; ""1.1.4 Zinc Finger Nuclease (ZFN)""; ""1.1.5 Transcription Activator-Like Effector Nucleases (TALENs)""; ""1.1.6 CRISPR/Cas9""; ""1.2 Off Target Effects""; ""2 CRISPR applications""; ""2.1 CRISPRi and CRISPRa: Regulation of Transcriptional Levels""; ""2.2 Epigenome Edition""; ""2.3 Genome Imaging""; ""2.4 Large-Scale Functional Genomic Studies Using CRISPR/Cas9""; ""2.5 Edition of Single-Stranded RNA"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""3 CRISPR applications in biomedical modeling""""3.1 Neurological Disease Models""; ""3.2 Cancer Models""; ""3.3 Cardiovascular Disease Models""; ""3.4 Infectious Disease Models""; ""3.5 Immunodeficiency Models""; ""4 Concluding remarks""; ""References""; ""Chapter Three -- Dynamics of Indel Profiles Induced by Various CRISPR/Cas9 Delivery Methods""; ""Abstract""; ""1 Introduction""; ""1.1 Genome Editing and DNA Repair""; ""1.2 Indel Detection Methodologies""; ""1.3 IDAA for Indel Detection and gRNA Selection""; ""2 Materials and methods""; ""2.1 gRNAs, Plasmid Vectors and Cell Lines"" |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | ""2.2 Cas9 and gRNA Delivery Conditions""""2.3 Efficiency Measurements""; ""3 Results""; ""3.1 Rationale and Design of the Study""; ""3.2 Transfection and Integration Dynamics""; ""3.3 Efficiency of Generating Indels Over Time""; ""3.4 Indel Profiles Over Time""; ""3.5 Dynamic Effect of gRNA Stability on Indel Efficiency""; ""3.6 Comparison of IDAA and TIDE Methods""; ""4 Concluding remarks""; ""Acknowledgments""; ""References""; ""Chapter Four -- CRISPR Libraries and Screening""; ""Abstract""; ""1 Introduction""; ""2 Mouse models of cancer""; ""3 CRISPR-Cas9 systems""; ""4 CRISPR libraries"" |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | Elsevier |
| Provenance (VM) [OBSOLETE] | ScienceDirect All Books |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetic engineering. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Gene therapy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Molecular genetics. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | SCIENCE / Chemistry / Industrial & Technical. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | TECHNOLOGY & ENGINEERING / Chemical & Biochemical. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Gene therapy. |
| Source of heading or term | fast |
| -- | (OCoLC)fst00939638 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetic engineering. |
| Source of heading or term | fast |
| -- | (OCoLC)fst00940027 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Molecular genetics. |
| Source of heading or term | fast |
| -- | (OCoLC)fst01024797 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genetic Engineering. |
| 655 #7 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| Source of term | local |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Torres-Ruiz, Raul, |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Roguez-Perales, Sandra, |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | ScienceDirect eBooks. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Print version: |
| International Standard Book Number | 9780128125069 |
| -- | 0128125063 |
| Record control number | (OCoLC)983822818 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Progress in molecular biology and translational science ; |
| Volume number/sequential designation | volume 152. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/bookseries/18771173/152">http://ezproxy.alfaisal.edu/login?url=https://www.sciencedirect.com/science/bookseries/18771173/152</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Library of Congress Classification |
| Koha item type | eBooks |
No items available.