MARC details
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05346cam a2200601Mu 4500 |
| 001 - CONTROL NUMBER |
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10986057 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20171207085556.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr cnu---unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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140913s2014 xx o 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780124167216 (Hardcover) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
9780124167285 (eBook) |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Terms of availability |
eng |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(NNC)10986057 |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)ocn890530087 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EBLCP |
| Language of cataloging |
eng |
| Transcribing agency |
EBLCP |
| Modifying agency |
AU |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Alfaisal Main Library |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RD675 |
| Item number |
.B384 2014 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.99471 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Heymann, Dominique. |
| 245 10 - TITLE STATEMENT |
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| Title |
Bone Cancer |
| Medium |
: |
| Remainder of title |
Primary Bone Cancers and Bone Metastases. |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
2nd ed. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Burlington : |
| Name of publisher, distributor, etc |
Elsevier Science, |
| Date of publication, distribution, etc |
©2014. |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE STATEMENTS |
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| Place of production, publication, distribution, manufacture |
Burlington : |
| Name of producer, publisher, distributor, manufacturer |
Elsevier Science, |
| Date of production, publication, distribution, manufacture |
©2014. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 online resource (730 p.) |
| 500 ## - GENERAL NOTE |
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| General note |
Description based upon print version of record. |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Cover; Title page; Copyright page; Table of Contents; List of Contributors; Foreword; Preface; Part I -- Basic aspects of bone cancers; Section 1 -- Epidemiology of bone cancer; Chapter 1 -- Epidemiology of primary bone tumors and economical aspects of bone metastases; Introduction; Incidence of primary bone tumors; Age; Gender; Site distribution; Incidence of bone tumors as a secondary event; Racial differences in incidence of primary bone tumors; Incidence of bone metastases; Pathology of bone metastases; Cost of illness; Economical burden of bone metastasis; Conclusions; References |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Linkage |
880-01 |
| Formatted contents note |
Bone-derived factors stimulating tumor cellsOther ways osteoclasts contribute to the bone-tumor niche; References; Chapter 6 -- Involvement of osteocytes in cancer bone niche; Introduction; Osteocytes: A multifunctional bone cell; Short overview of RANK/RANKL/osteoprotegerin and canonical Wnt signaling pathways; Central role of osteocytes in bone remodeling through RANKL and sclerostin regulation; Deregulation of RANK/RANKL and Wnt pathways in malignancy; Is there a direct link between malignant cells and osteocytes?; Conclusions and perspectives; References |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Chapter 7 -- Role of mesenchymal stem cells in bone cancer |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Niche and microenvironmentOsteoblastic and endothelial niches; Bone marrow stromal cells and the niche; The heterotopic transplantation system; An adaptive niche; Modeling the niche and probing its significance in disease; The niche in early metastatic growth; Acknowledgments; References; Chapter 4 -- Deregulation of osteoblast differentiation in primary bone cancers; Introduction; Normal osteoblastogenesis: general process and major regulatory mechanisms; Deregulated genes in bone tumors; Tumor suppressor genes; Oncogenes; Transcription factors; Deregulated signaling pathways in bone tumors |
| 505 8# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Section 2 -- Bone microenvironmentand bone cancerChapter 2 -- Tumor-bone interactions: there is no place like bone; Introduction; Making its way to bone; Disseminated tumor cells and dormancy in bone; Induction of osteolysis by cancer cells in bone; Induction of bone formation by cancer cells in bone; Suppression of bone formation; The bone microenvironment support cancer cell growth; Conclusion; References; Chapter 3 -- Stem cell niches in the bone-bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer; Introduction; The concept of a niche |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been wri. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Bones |
| General subdivision |
Cancer |
| -- |
Treatment. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Bones |
| General subdivision |
Cancer. |
| 650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Bone neoplasms. |
| 650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Bones -- Cancer -- Treatment. |
| 650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Bones -- Cancer. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
HEALTH & FITNESS / Diseases / General |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
MEDICAL / Clinical Medicine |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
MEDICAL / Diseases |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
MEDICAL / Evidence-Based Medicine |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
MEDICAL / Internal Medicine |
| Source of heading or term |
bisacsh |
| 655 #7 - INDEX TERM--GENRE/FORM |
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| Genre/form data or focus term |
Print books. |
| Source of term |
local |
| 880 8# - ALTERNATE GRAPHIC REPRESENTATION |
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| Linkage |
505-01/(S |
| a |
Bone morphogenetic protein BMP and transforming growth factor-(Sb (B(TGF-(Sb(B) signalingReceptor tyrosine kinase signaling; Intracellular signaling pathways; Wnt signaling; Deregulation of local regulatory mechanisms in bone tumors; Cell-cell interactions; Cell-matrix interactions; Microenvironmental factors; Conclusions and perspectives; Acknowledgments; References; Chapter 5 -- Contribution of osteoclasts to the bone-tumor niche; Introduction; Osteoclastogenesis; Bone resorption; The vicious cycle of tumor-bone metastases; Tumor-derived factors stimulating osteoclasts |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
BOOKS |
