General Aspects of Dendritic Cell Biology, Functions, and Clinical Application -- Dendritic Cell Biology: Subset Heterogeneity and Functional Plasticity -- Dendritic Cells and Their Role in Linking Innate and Adaptive Immune Responses -- Dendritic Cell and Pathogen Interactions in the Subversion of Protective Immunity -- Dendritic Cells as Keepers of Peripheral Tolerance -- Adjuvants, Dendritic Cells, and Cytokines: Strategies for Enhancing Vaccine Efficacy -- Ex Vivo–Generated Dendritic Cells for ClinicalTrials versus In Vivo Targeting to Dendritic Cells: Critical Issues -- General Aspects of the Pathogenesis and Immune Response to HIV-1 Infection -- Immunopathogenesis of HIV Infection -- Innate Cellular Immune Responses in HIV Infection -- Adaptative Immune Responses in HIV-1 Infection -- Dendritic Cells and HIV Interactions and Their Role in Pathogenesis and Immunity -- Binding and Uptake of HIV by Dendritic Cellsand Transfer to T Lymphocytes: Implicationsfor Pathogenesis -- Loss, Infection, and Dysfunction of Dendritic Cells in HIV Infection -- HIV Exploitation of DC Biology to Subvertthe Host Immune Response -- Cross-Presentation by Dendritic Cells: Rolein HIV Immunity and Pathogenesis -- Immunotherapy of HIV Infection: Dendritic Cells as Targets and Tools.

This comprehensive volume, written by experts in the field, is the first to address the biology of dendritic cells (DCs) in an integrated fashion, in the context of HIV infection and immunity. The book brings together the most recent information related to the biology of DCs and their role in the pathogenesis and immunity of HIV-1 infection. Recent research in immunology has revealed the key importance of DCs in the regulation of the immune response to infections and that DCs are important targets and reservoirs of HIV, playing a critical role in several aspects of viral pathogenesis and immunity. The Biology of Dendritic Cells and HIV Infection is an ideal book for researchers, clinicians, physicians, and graduate students in the fields of basic and applied immunology, virology, cell biology and vaccine development.