1. Identification and Biology of CML Stem Cells.- 2. Molecular Mechanisms of CML Stem Cell Maintenance -- 3. Roles for Signaling Molecules in the Growth and Survival of CML Cells.- 4. Goal of CML Treatment in the Tyrosine Kinase Inhibitor Era.- 5. Biomarkers for Determining the Prognosis of CML -- 6. Updated European Leukemia Net Recommendations for the Management of CML -- 7. Optimal Monitoring of CML Treatment: Molecular and Mutation Analysis -- 8. Recommendations for Management of CML in the Era of Second-Generation TKIs -- 9. Role of New TKIs and Combinations with Interferon-α for the Treatment of CML -- 10. Safety Profiles of First-Line TKIs and Managing Adverse Effects -- 11. Molecular Mechanism of TKI Resistance and Potential Approaches to Overcome Resistance -- 12. Discontinuation of Therapy and Treatment-Free Remission in CML.

Covering the history of breast cancer, theory of radiofrequency ablation (RFA), resection of carcinoma, imaging before and after non-surgical ablation therapy and quality of life, this book focuses on extensive breast-conserving treatment for the preservation of a cosmetically acceptable breast. It investigates the feasibility of percutaneous, minimally invasive techniques to ablate breast tumors and several modalities such as cryosurgery, laser ablation, thermoablation and high-intensity focused ultrasound. Non-surgical Ablation Therapy for Early-stage Breast Cancer centers on RFA and provides insights into cryoablation and focused ultrasound surgery. RFA has been shown to be effective for treating tumors in many types of tissue, including liver, bone, brain, kidney, pancreas and prostate. As such this book is a valuable resource for breast and general surgeons, radiation oncologists and medical oncologists in all areas. The extensive discussions enable scholars to gain radiological expertise and a basic understanding of molecular biology, leading to better surgery without scalpels.