Cortico-Subcortical Circuits and Parkinson’s Disease -- Leading Toward a Unified Cortico-basal Ganglia Functional Model -- Modeling Parkinson’s Disease: 50 Years Later -- Physiological Studies of the Cortico-subcortical Dynamics and Parkinson’s Disease -- Phasic Dopaminergic Signaling: Implications for Parkinson’s Disease -- Striatal Dendritic Adaptations in Parkinson’s Disease Models -- Diversity of Up-State Voltage Transitions During Different Network States -- The Corticostriatal Pathway in Parkinson’s Disease -- Cholinergic Interneuron and Parkinsonism -- Basal Ganglia Network Synchronization in Animal Models of Parkinson’s Disease -- Converging into a Unified Model of Parkinson’s Disease Pathophysiology -- The Corticostriatal Transmission in Parkinsonian Animals: In Vivo Studies -- Striatal Nitric Oxide–cGMP Signaling in an Animal Model of Parkinson’s Disease -- Dopamine–Endocannabinoid Interactions in Parkinson’s Disease -- Glutamate Plasticity in an Animal Model of Parkinson’s Disease -- Computational Analyses of the Cortico-Subcortical Dynamics and Parkinson’s Disease -- Neuromodulation and Neurodynamics of Striatal Inhibitory Networks: Implications for Parkinson’s Disease -- Dopaminergic Modulation of Corticostriatal Interactions and Implications for Parkinson’s Disease -- Neurobiology and Pathophysiology of Parkinson's Disease -- Pathogenesis of Oxidative Stress and the Destructive Cycle in the Substantia Nigra in Parkinson’s Disease -- Regulation of G-Protein-Coupled Receptor (GPCR) Trafficking in the Striatum in Parkinson’s Disease -- Atypical Parkinsonism in the French West Indies: The Plant Toxin Annonacin as a Potential Etiological Factor -- Cognitive Deficits in Parkinson’s Disease -- Pharmacological and Non-Pharmacological Treatments in Parkinson’s Disease -- Dopamine Replacement Therapy in Parkinson’s Disease: Past, Present and Future -- Molecular, Cellular and Electrophysiological Changes Triggered by High-Frequency Stimulation of the Subthalamic Nucleus in Animal Models of Parkinson’s Disease -- Surgical Strategies for Parkinson’s Disease Based on Animal Model Data: GPi and STN Inactivation on Various Aspects of Behavior (Motor, Cognitive and Motivational Processes) -- Antidromic Cortical Activity as the Source of Therapeutic Actions of Deep Brain Stimulation -- Cell-Based Replacement Therapies for Parkinson’s Disease.

Cortico-subcortical dynamics in Parkinson’s disease aims to integrate key pathophysiological aspects underlying Parkinson’s disease. The volume offers a broad spectrum of opinions on how chronic dopamine depletion affects cortico-subcortical dynamics, especially how disruptions of the non-dopaminergic systems resulting from chronic dopaminergic degeneration could lead to the functional alterations observed in parkinsonism. About the Editor: Dr. Kuei Y. Tseng is Assistant Professor in the Department of Cellular and Molecular Pharmacology at Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA.