Effects of preanalytical variables on the quality of biospecimens used to study genetic changes in cancer : development of the biospecimen research database / Elisa Eiseman.

By:

Eiseman, Elisa [author.]

Contributor(s):

Rand eBooks

Series: Documented briefing (Rand Corporation) ; 572.Publisher: Santa Monica, CA : RAND, 2009Description: xxii, 76 pages : illustrations ; 28 cmContent type:

text

Media type:

computer
unmediated

Carrier type:

online resource
volume

ISBN:

0833047418
9780833047410

Subject(s):

Genre/Form:

Electronic books.

LOC classification:

RD129 .E37 2009

Online resources:

Click here to access online

Available additional physical forms:

Also available on the internet via WWW in PDF format.

Contents:

Introduction -- Developing the Data-Curation Tool -- Literature-Search Strategies to Identify Studies on the Effects of Preanalytical Variables -- Data Analysis and Study Results -- Challenges and Next Steps -- Appendix: Reference List for Papers Analyzed in the Biospecimen Research Database.

Summary: The National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research (OBBR) asked the RAND Corporation to identify and analyze existing data on the effects of preanalytical variables on biospecimens used to study genetic and proteomic changes in cancer. The project was broken down into three phases. This documented briefing, which focuses on work conducted during the first year of this project, describes the process used to identify and analyze data on the effects of preanalytical variables on biospecimens used to study genetic and proteomic changes in cancer. It provides details on the development of the Biospecimen Research Database, a data-curation tool developed to provide a standardized way of consistently recording data on the effects of preanalytical variables, and summarizes the findings of the first phase of the study. This documented briefing is based on the briefing given to OBBR on September 27, 2007, and provides OBBR with a framework for analyzing the effects of preanalytical variables on various biospecimen types, research questions, and analytic methods. The ultimate goal of the database is to provide information to OBBR and the scientific community that will optimize the quality, accessibility, and utility of biospecimens for research purposes.

Item type:

eBooks

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Includes bibliographical references (p. 63-76).

The National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research (OBBR) asked the RAND Corporation to identify and analyze existing data on the effects of preanalytical variables on biospecimens used to study genetic and proteomic changes in cancer. The project was broken down into three phases. This documented briefing, which focuses on work conducted during the first year of this project, describes the process used to identify and analyze data on the effects of preanalytical variables on biospecimens used to study genetic and proteomic changes in cancer. It provides details on the development of the Biospecimen Research Database, a data-curation tool developed to provide a standardized way of consistently recording data on the effects of preanalytical variables, and summarizes the findings of the first phase of the study. This documented briefing is based on the briefing given to OBBR on September 27, 2007, and provides OBBR with a framework for analyzing the effects of preanalytical variables on various biospecimen types, research questions, and analytic methods. The ultimate goal of the database is to provide information to OBBR and the scientific community that will optimize the quality, accessibility, and utility of biospecimens for research purposes.

Also available on the internet via WWW in PDF format.

Description based on print version record.