Includes bibliographical references and index

Introduction to biopharmaceutics and pharmacokinetics -- Mathematical fundamentals in pharmacokinetics -- Biostatistics -- One-compartment open model : intravenous bolus administration -- Multicompartment models : intravenous bolus administration -- Intravenous infusion -- Drug elimination, clearance, and renal clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutical aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified-release drug products and drug devices -- Targeted drug delivery systems and biotechnological products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Application of pharmacokinetics to specific populations : geriatric, obese, and pediatric patients -- Dose adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moments, and noncompartmental analysis