This sequel to the highly successful and much appreciated "Modern Aldol Reactions" continues to provide a systematic overview of methodologies for installing a required configuration during an aldol addition step, but shifts the focus so as to cover the latest developments. As such, it presents a set of brand new tools, including vinylogous Mukaiyama-aldol reactions, substrate-controlled aldol reactions and asymmetric induction in aldol additions. Furthermore, novel developments in existing stereoselective aldol additions are described, such as the deployment of supersilyl groups or organocatalyzed aldol additions. Throughout, all of these methodologies are presented in the context of their deployment in total synthesis of natural products.

Includes bibliographical references and index.

Stereoselective Acetate Aldol Reactions / Pedro Romea, Fèlix Urpí -- The Vinylogous Mukaiyama Aldol Reaction in Natural Product Synthesis / Martin Cordes, Markus Kalesse -- Organocatalyzed Aldol Reactions / Gabriela Guillena -- Supersilyl Protective Groups in Aldol Reactions / Patrick B Brady, Hisashi Yamamoto -- Asymmetric Induction in Aldol Additions / Luiz C Dias, Ellen C Polo, Emílio C de Lucca, Marco A B Ferreira -- Polypropionate Synthesis via Substrate-Controlled Stereoselective Aldol Couplings of Chiral Fragments / Dale E Ward -- Application of Oxazolidinethiones and Thiazolidinethiones in Aldol Additions / Michael T Crimmins -- Enzyme-Catalyzed Aldol Additions / Pere Clapés, Jesús Joglar.

John Wiley and Sons Wiley eBooks