Includes bibliographical references and index.

The SnAr Reactions: Mechanistic Aspects -- Structure and Reactivity of Anionic [alpha]-Complexes -- The Superelectrophilic Dimension in SnAr and Related [alpha]-Complexation Processes -- Synthetic Aspects of Intermolecular SnAr Reactions -- Intramolecular SnAr Reactions -- Nucleophilic Aromatic Substitutions of Hydrogen -- Other SnAr Substitution Pathways.

This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions. The first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to define the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, chapter 2 then discusses the chemistry of anionic sigma-complexes.

John Wiley and Sons Wiley eBooks