Human drug metabolism : an introduction / Michael D. Coleman
By: Coleman, Michael D.
Publisher: Oxford, England ; Hoboken, NJ : Wiley-Blackwell, c2010Edition: 2nd ed.Description: xiv, 346 p. : ill. ; 26 cm.ISBN: 9780470742167 (pbk.).Subject(s): Drugs -- Metabolism | Xenobiotics -- Psychological aspects | Pharmaceutical Preparations -- metabolism | Xenobiotics -- toxicityGenre/Form: Print books.Abstract: (Publisher-supplied data) Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs| Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|
| On Shelf | RM301.55 .C65 2010 (Browse shelf) | Available | AU0000000007482 |
Browsing Alfaisal University Shelves , Shelving location: On Shelf Close shelf browser
|
|
|
|
|
|
|
||
| RM301.5 .R655 2011 Basic pharmacokinetics and pharmacodynamics : an integrated textbook and computer simulations / | RM301.5 R655 2017 Basic pharmacokinetics and pharmacodynamics : an integrated textbook and computer simulations / | RM301.5 .T93 2016 Essentials of pharmacokinetics and pharmacodynamics / | RM301.55 .C65 2010 Human drug metabolism : an introduction / | RM301.55 .U382 2007 Drug metabolism chemical and enzymatic aspects / | RM301.65 .M65 2013 Molecular pharmacology : from DNA to drug discovery / | RM302 .C46 2011 Drug actions and interactions / |
Includes bibliographical references (p. [319]-327) and index
(Publisher-supplied data) Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs