Includes index.

Title Page -- Copyright Page -- Contents -- Preface to the seventh edition -- From the preface to the first edition -- Key to symbols used in this edition -- Overview of the immune system -- Part 1 Immunity and the Immune System -- Chapter 1 The nature of immunity -- Recognition and defence components -- Innate and adaptive immunity -- Stages of an immune response -- Immunological defence strategies -- An overview -- Immunopathology -- Self-assessment questions -- Notes -- Chapter 2 Immune recognition -- Recognition of PAMPs -- Recognition of antigens -- The HLA system and its proteins.

Self-assessment questions -- Chapter 3 Lymphocyte development and activation -- B-cell development -- B-cell activation and maturation -- T-cell development and education -- T-cell subpopulations -- Self-assessment questions -- Chapter 4 Lymphocyte interactions, cytokines and the lymphoid system -- Cytokines and T-cell subpopulations -- The lymphoid system -- Lymphocyte recirculation and homing -- Lymphocyte selection and maturation -- Laboratory methods -- Self-assessment questions -- Chapter 5 Immunoglobulins -- Structure -- Classes and subclasses -- Triggering of effector systems.

Immunoglobulin genes -- Exploiting the properties of immunoglobulins: Laboratory methods -- Self-assessment questions -- Chapter 6 Complement -- The classical pathway (Fig. 6.3) and the lectin pathway -- The alternative pathway (Fig 6.5) -- The membrane attack pathway (Fig. 6.2) -- Inadequate regulation of complement activation -- Complement polymorphisms and deficiencies -- Self-assessment questions -- Chapter 7 Phagocytes -- Macrophages -- Neutrophils -- Common features of phagocyte responses -- Self-assessment questions -- Chapter 8 Mast cells, basophils and eosinophils.

Triggering of mast cells and basophils -- Mast cell mediators -- Eosinophils -- Cooperation between mast cells, basophils and eosinophils -- Self-assessment questions -- Chapter 9 Killer cells -- Mechanisms of target cell recognition -- Mechanisms of target cell killing -- Cooperation between killer cells and interferons -- Self-assessment questions -- Part 2 Immunopathology -- Chapter 10 Immunity and infection -- Defence against infection -- Mechanisms of evasion -- The inflammatory response -- Regulation of immune and inflammatory responses -- Diagnosis of microbial infection.

Opportunistic infection -- Chronic inflammatory diseases of unknown cause -- The host-pathogen interface -- Self-assessment questions -- Chapter 11 Primary and secondary immunodeficiency disorders -- Important clues -- Investigation of suspected immunodeficiency -- Primary or secondary immunodeficiency -- Severe combined immunodeficiency -- Thymic hypoplasia (DiGeorge syndrome -- 22q11 deletion syndromes) -- T-cell deficiencies -- Defects in mediator production and the innate immune system -- NK cell defects -- B-cell deficiencies: Hypogammaglobulinaemia.

Other forms of hypogammaglobulinaemia (Table 11.4)

Immunology Lecture Notes provides a thorough grounding in basic concepts of immunity. Covering the core components of the immunology curriculum at medical school, it presents a concise overview of the immune system, its interactions with pathogens, the major areas of immunopathology, including immunodeficiency, allergy, autoimmunity, lymphoptopliferative diseases and transplantation, and their therapy. Immunology Lecture Notes includes: Full-colour descriptive illustrations and diagrams throughout, supplemented by new molecular graphics and anatomical scans New cli.