Includes bibliographical references and index.

Cover -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Therapeutic Cloning and Tissue Engineering -- I. Introduction -- II. Principles of Tissue Engineering -- III. Stem Cells -- IV. Therapeutic Cloning -- V. Applications of Tissue Engineering and Therapeutic Cloning -- References -- Chapter 2. a-Synuclein: Normal Function and Role in Neurodegenerative Diseases -- I. Introduction to the Synuclein Protein Family -- II. Synuclein in Synaptic Development and Maintenance -- III. Synuclein Protein Interactions -- IV. Synucleinopathies -- V. Structural Properties of a-Synuclein Protein -- VI. Implications of Oxidative and Nitrative Injury in Synucleinopathies -- VII. Effects of Oxidation and Nitration on a-Synuclein Fibril Formation -- VIII. Possible Role of Pesticides and Other Toxic Chemicals in PD -- IX. Transgenic and Nontransgenic Animal Models of Synucleinopathies -- X. Concluding Remarks -- Acknowledgments -- References -- Chapter 3. Structure and Function of Eukaryotic DNA Methyltransferases -- I. DNA Methylation: A Heritable Epigenetic Mark -- II. Eukaryotic DNA Methyltransferases -- III. Function of DNA Methylation -- IV. Concluding Remarks -- Acknowledgments -- References -- Chapter 4. Mechanical Signals as Regulators of Stem Cell Fate -- I. Introduction -- II. Mechanical Regulation of Limb Development -- III. Theoretical Models of Mechanical Stress in Development -- IV. In Vivo Experimentation -- V. In Vitro Experimentation -- VI. Conclusions -- Acknowledgment -- References -- Chapter 5. Origins of Mammalian Hematopoiesis: In Vivo Paradigms and In Vitro Models -- I. Introduction: The Hematopoietic System -- II. Hematopoiesis: De Muribus et Maribus -- III. Points of Divergence Between Murine and Human Blood Formation -- IV. Hematopoiesis from Embryonic Stem Cells -- V. What Remains To Be Learned? -- VI. Summary -- Acknowledgments -- References -- Chapter 6. Regulation of Gene Activity and Repression: A Consideration of Unifying Themes -- I. Introduction -- II. Regulation of Imprinted Gene Activity and Repression -- III. A Consideration of Recurrent Themes -- References -- Chapter 7. Molecular Basis for the Chloride Channel Activity of Cystic Fibrosis Transmembrane Conductance Regulator and the Consequences of Disease-Causing Mutations -- I. Introduction -- II. Role of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Function in Tissue Physiology and Pathophysiology -- III. Cell Biology of CFTR and the Major CF Mutant (delta F508) -- IV. Quaternary Structure of CFTR -- V. The Permeation Pore of CFTR -- VI. Molecular Basis for Regulation by Phosphorylation -- VII. Molecular Basis for Regulation by Nucleotides -- VIII. Future Directions -- Acknowledgments -- References -- Index -- Contents of Previous Volumes -- Last Page.

This volume of Current Topics in Developmental Biology showcases the research and therapeutic value of stem cells, and is proof of the increasing maturation of the fields of regenerative and molecular medicine. Reviews include:* Therapeutic cloning and tissue engineering to produce functional replacement tissues.* The role of the protein a-synuclein in a host of neurodegenerative diseases, which may be the first to benefit from stem cell therapy.* The curious array of functions in eukaryotic DNA methyltransferase, crucial for normal development and at the core of epigenetics regulation.* Influ.

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