Includes bibliographical references and index.

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Front Cover; Advavces in Immunology, Volume 50; Copyright Page; Contents; Chapter 1. Selective Elements for the Vß Region of the T Cell Receptor: Mls and the Bacterial Toxic Mitogens; I. Introduction; II. The Working Model for Vß Selective Elements; Ill. Vß Selective Elements; IV. The Molecular Basis of Vß Selective Element Action; V. The Cellular Basis of Vß Selective Element Action; VI. The Impact of Vß Selective Elements on T Cell Development and Function; VII. Vß Selective Elements are Encoded by Endogenous or Extrinisic Retroviruses; VIII. Unanswered Questions About Vß Selective Elements.

IX. ConclusionsReferences; Chapter 2. Programmed Cell Death in the Immune System; I. Introduction and Definitions; II. Mechanisms of Programmed Cell Death; III. Programmed Cell Death in Immunologic Systems; IV. Triggering and Regulation of Programmed Cell Death; V. Conclusions; References; Chapter 3. Avian T Cell Ontogeny; I. Introduction; II. Avian T Cell Differentiation Antigens; Ill. Thymocyte Precursors: Origin and Thymic Attraction; IV. Diversification in the Thymus; V.T Cell Migration to the Periphery; VI. Functional Capabilities of TCRl, TCR2, and TCR3 Cells.

VII. Experimental Manipulation of T Cell DevelopmentVIII. T Cell Tumors; IX. TCR Genes; X. Concluding Remarks; References; Chapter 4. Structural and Functional Chimerism Results from Chromosomal Translocation in Lymphoid Tumors; I. Introduction; II. Mechanism of Translocation and Inversion; III. Timing of Chromosome Translocation and Inversion; IV. Consequences of the Formation of Chromosomal Abnormalities on Adjacent Oncogenes; V. Effects of Chromosomal Abnormalities on Lymphoid Cells; VI. The Development of T Cell Leukemia: A Paradigm for Clonal Evolution and Tumor Development; References.

Chapter 5. Interleukin-2, Autotolerance, and AutoimmunityI. Introduction; II. Physiology of Interleukin-2 and Its Receptor; III. IL-2 and Autotolerance; IV. IL-2 in Autoimmunity-Phenomenology; V. IL-2 in Autoimmunity-In Vivo Interventions; VI. Role of IL2-Induced Cytokines in Autoimmunity; VII. Concluding Remarks; References; Chapter 6. Histamine Releasing Factors and Cytokine-Dependent Activation of Basophils and Mast Cells; I. Introduction; II. Purification of Histamine Releasing Factors; Ill. The Cell Source(s) of HRF; IV. Mechanism of Action of Human HRFs.

V. Cytokines and Histamine ReleaseVI. Modulation of Histamine Release by Cytokines; VII. Clinical Considerations; Referenccs; Chapter 7. Immunologic Interactions of T Lymphocytes with Vascular Endothelium; I. Introduction; II. Specific Antigen Presentation by Vascular Endothelial Cells; Ill. Costimulator Activities of Vascular Endothelial Cells; IV. Antigen-Independent Recruitment of T Lymphocytes into Tissues by Endothelial Cells; V. Summary; References.

Celebrating the publication of our fiftieth volume.

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