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KEY TOPICS: Ig A Deficiency The Role of Cellular Immunity in Protection against HIV Infection Mouse Mammary Tumour Virus: Immunological Interplays between Virus and Host The Transporter Associated with Antigen Processing NF-kB in cytokine gene expression NF-kB as a target for immunosuppressive and anti-inflammatory molecules Key Features * A Deficiency * The Role of Cellular Immunity in Protection against HIV Infection * Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host * The Transporter Associated with Antigen Processing * NF-kB in cytokine gene expression * NF-kB as a target for immunosuppressive and anti-inflammatory molecules.

Front Cover; Advances in Immunology, Volume 65; Copyright Page; Contents; Contributors; Chapter 1. NF-IL6 and NF-KB in Cytokine Gene Regulation; I. Introduction; II. NF-IL6; III. NF-KB; IV. Protein-Protein Interaction in Gene Regulation; V. Cytokine Gene Regulation; VI. Cytokine Induction in NF-IL6 Family Knockout Mice; VII. Cytokine Induction in NF-KB Knockout Mice; VIII. Conclusion; References; Chapter 2. Transporter Associated with Antigen Processing; I. Introduction; II. ABC Transporters; III. Gene Structure of TAP and Its Regulation; IV. TAP Protein Structure; V. TAP Polymorphism.

VI. Function of the TAP ComplexVII. TAP and MHC Class I Assembly; VIII. TAP in Disease; IX. Concluding Remarks; References; Chapter 3. Contents NF-KB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules; I. Introduction; II. Glucocorticoids and Other Steroid Hormones; III. Cyclosporin A and FK506; IV. Rapamycin; V. Salicylates; VI. Antioxidants and Inhibitors of Enzymes Generating Reactive Oxygen Intermediates; VII. Anti-TNF-a Antibodies and Gold Compounds in Treatment of Rheumatoid Arthritis; VIII. Immunosuppressive Activity of cAMP.

IX. The Bacterial Metabolite SpergualinX. The Fungal Metabolite Gliotoxin; XI. Viral Strategies to Control NF-KB; XII. Conclusion; References; Chapter 4. Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host; I. Introduction; II. Mouse Mammary Tumor Virus; III. Structure of the SAg Protein; IV. Immune Response to MMTV; V.T and B Cell Response to Endogenous Mtv; VI. Comparison with Other SAgs; VII, Conclusions; Chapter 5. IgA Deficiency; I. Introduction; II. Clinical Manifestations of IgA Deficiency; III. IgA Structure, Production, and Function.

IV. IgA Deficiency Viewed in the Context of the Genesis of IgA-Producing CellsV. Relationship of IgA D with Common Variable Immunodeficiency; VI. Genetic Susceptibility for IgAD and CVID; VII. Pathogenesis of IgA Deficiency; VIII. Conclusions; References; Chapter 6. Role of Cellular Immunity in Protection against HIV Infection; I. Introduction; II. Cellular Immunity in the Control of Other Viruses; III. CTL Effector Mechanisms; IV. HLA and HIV Infection; V. The Nature of HIV-Specific CTLs; VI. Measurement of HIV-Specific CTLs.

VII. Role of HIV-Specific CTLs in the Natural History of HIV InfectionVIII. Does HIV Escape from the CTL Response?; IX. Therapeutic Implications of the Importance of HIV-Specific CTLs; X. Conclusions; References; Chapter 7. High Endothelial Venules: Lymphocyte Traffic Control and Controlled Traffic; I. Introduction; II. Structure of High Endothelial Venules; III. Role of HEVs and Lymphocyte Migration; IV. In Vitro HEV Binding Assay; V. Molecules Determining HEV-Lymphocyte Interactions; VI. L Selectin; VII. Integrins and Their Role in Lymphocyte-HEV Interactions.

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