Includes bibliographical references and index.

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Front Cover; Advances in Immunology, Volume 68; Copyright Page; Contents; Contributors; Chapter 1. Posttranscriptional Regulation of mRNAs Important in T Cell Function; I. Introduction; II. Measurement of mRNA Decay Rates; III. Measurement of Translation; IV. mRNAs Regulated by Posttranscriptional Control; V. cis Elements; VI. trans Factors; VII. Concluding Remarks; References; Chapter 2. Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis; I. Introduction; II. Degradation Phase of Apoptosis; III. Effector Phase of Apoptosis; IV. Initiation Phase of Apoptosis; V. Conclusions.

XII. Role of Ras GTPase Family Members in Immunobiology:The Ras PathwayXIII. The Rho/Rac Pathway and Leukocyte Function; XIV. Regulation of the Neutrophil NADPH Oxidase by Rac and Rap; XV. Regulation of Phospholipase D by RhoA; XVI. Role of C-Terminal Methylation of Prenylated Proteins in NADPH Oxidase Regulation and Other Leukocyte Functions; XVII. Role of Rab Proteins in Membrane Transport in Leukocytes; XVIII. Regulation of Vesicular Transport by Rho Proteins; XIX. Other Prenylated Proteins; XX. Prenyltransferase Inhibitors; XXI. Effects of Prenylation Inhibitors on Leukocyte Function.

XXII. ConclusionReferences; Chapter 4. Generation and TAP-Mediated Transport of Peptides for Major Histocompatibility Complex Class I Molecules; I. Introduction; II. TAP as the Principal Peptide Supplier for MHC Class I Molecules; III. Generation of Antigenic Peptides from Endogenous Antigens; IV. Peptide Loading of Class I Molecular in the ER; V. TAP Genes and Their Regulation; VI. TAP Protein in Different Species; VII. TAP as a Member of the ABC Transporter Superfamily; VIII. Structure of TAP Molecules; IX. In Vitro Assays for Peptide Binding and Transport by TAP.

X. Substrate Specificity of Peptide TransportXI. Biochemic ap Characteristics of Peptide Transport; XII. Linking TAP Structure and Function; XIII. Export of Peptides from the ER; XIV. Involvement of TAP in Diseases; XV. Concluding Remarks; References; Chapter 5. Adoptive Tumor Immunity Mediated by Lymphocytes Bearing Modified Antigen-Specific Receptors; I. Adoptive Tumor Therapy; II. Single-Chain Fv Receptors; III. New Approaches; References; Chapter 6. Membrane Molecules as Differentiation Antigens of Murine Macrophages; I. Introduction.

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