Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. Includes many descriptive figures. Topics covered include Wnt signaling, controlling regulatory networks, cartilage growth plates, and more.

BMP Signaling in the Cartilage Growth Plate -- The CLIP-170 Orthologue Bik1p and Positioning the Mitotic Spindle in Yeast -- Aggregate-Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications -- Wnt Signaling: A Key Regulator of Bone Mass -- Eukaryotic DNA Replication in a Chromatin Context -- The Regulatory Network Controlling the Proliferation-Meiotic Entry Decision in the Caenorhabditis elegans Germ Line -- Regulation of Angiogenesis by Hypoxia and Hypoxia-Inducible Factors.

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ReferencesChapter 2: The CLIP-170 Orthologue Bik1p and Positioning the Mitotic Spindle in Yeast; I. Introduction; II. Structure of the Bik1 Protein; III. Bik1p Interactions with Other Proteins; Iv. Phenotypes and Activities; V. Role of Bik1p in Spindle Positioning; VI. Models for Plus-End Binding; VII. Regulation of CLIP-170 and Bik1p by Phosphorylation; VIII. Bik1p at the Kinetochore; IX. Bik1p in Genomic Studies; X. Concluding Remarks and Perspective; Acknowledgments; References; Chapter 3: Aggregate-Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications.

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