Includes bibliographical references and index.

Introduction and Overview of DNA Repair Targets: From Bench to Clinic -- MGMT: A Critical DNA Repair Gene Target for Chemotherapy Resistance and for Stem Cell Protection -- Blockade of Base Excision Repair: Inhibition of Small Lesions Results in Big Consequences to Cancer Cells -- The Role of PARP in DNA Repair and its Therapeutic Exploitation -- Chemotherapeutic Intervention by Inhibiting DNA Polymerases -- Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications -- Targeting Homologous Recombination Repair in Cancer -- DNA Double-Strand Break Repair by Non-homologous End Joining and Its Clinical Relevance -- Defective DNA Mismatch Repair-dependent c-Abl-p--₃-GADD₄₅a Expression Confers Cancer Chemoresistance -- Checkpoint Kinase and Wee1 Inhibitors as Anticancer Therapeutics -- Apurinic/Apyrimindinic Endonuclease in Redox Regulation and Oxidative Stress: Implications for Regulation of DNA Repair and Therapeutic Development -- Personalized Cancer Medicine: DNA Repair Alterations Are Promising Predictive Biomarkers in Cancer -- The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies -- Future Directions with DNA Repair Inhibitors: A Roadmap for Disruptive Approaches to Cancer Therapy.

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