Description based on print version record.

Includes bibliographical references and index.

Front Cover; Therapy for Severe Psoriasis; Therapy for Severe Psoriasis; Copyright ; Contributors; EDITORS; AUTHORS; Foreword; Preface; ACKNOWLEDGMENTS; Contents; Therapy for Severe Psoriasis; 1. Chapter 1 -- Overview of Psoriasis; KEY POINTS; EPIDEMIOLOGY; AGE OF ONSET; Cause and Pathogenesis; DEVELOPMENT OF A LESION; T CELLS; MACROPHAGES AND DENDRITIC CELLS; NEUTROPHILS; UNINVOLVED PSORIATIC SKIN; CLINICAL FINDINGS; History; CUTANEOUS LESIONS; Psoriasis Vulgaris; Guttate Psoriasis; Inverse Psoriasis (Flexural Psoriasis); Erythrodermic Psoriasis; Pustular Psoriasis.

Generalized Pustular Psoriasis (von Zumbusch)Annular Pustular Psoriasis and Impetigo Herpetiformis; Localized Pustular Psoriasis Variants; Napkin Psoriasis; Linear Psoriasis; RELATED PHYSICAL FINDINGS; Nail Findings; PSORIATIC ARTHRITIS; LABORATORY TESTS; COMPLICATIONS; MODIFYING FACTORS; TREATMENT; TOPICAL THERAPIES; CORTICOSTEROIDS; VITAMIN D3 AND ANALOGUES; TAZAROTENE; TOPICAL CALCINEURIN INHIBITORS; SALICYLIC ACID; BLAND EMOLLIENTS; PHOTOTHERAPY; ORAL AGENTS; BIOLOGIC THERAPY; REFERENCES; 2. Chapter 2 -- Ultraviolet B Phototherapy; KEY POINTS; INTRODUCTION; Definition; History; Types.

Broadband ultraviolet B (290-320 nm)Narrowband ultraviolet B (311-313 nm); TARGETED PHOTOTHERAPY; TANNING BEDS; INDICATIONS; MECHANISM OF ACTION; EFFICACY; Broadband Ultraviolet B; Narrowband Ultraviolet B; TARGETED PHOTOTHERAPY; TANNING BEDS; SAFETY; TARGETED PHOTOTHERAPY; TANNING BEDS; PRECAUTIONS; MONITORING; TARGETED PHOTOTHERAPY; VACCINATIONS; SUMMARY; REFERENCES; 3. Chapter 3 -- Psoralen-Ultraviolet Light A Therapy; KEY POINTS; INTRODUCTION; MECHANISM OF ACTION; EFFICACY; Combination Therapy; DOSING; SAFETY; Nonmelanoma Skin Cancer; Malignant Melanoma; PRECAUTIONS; Contraindications.

Special PopulationsPregnancy and lactation; Children; MONITORING; VACCINATION; SUMMARY; REFERENCES; 4. Chapter 4 -- Methotrexate; KEY POINTS; INTRODUCTION; MECHANISM OF ACTION; EFFICACY; CHAMPION; RESTORE1; M10-255; SMALLER STUDIES; EFFICACY IN REDUCTION OF IMMUNOGENICITY; EFFICACY IN PSORIATIC ARTHRITIS; SAFETY; CHAMPION; RESTORE1; Toxicity; Drug and Food Interactions; PRECAUTIONS; Myelosuppression; Hepatotoxicity; Pulmonary Fibrosis; Patients with Excessive Third Space Fluids; Teratogenicity; Pediatric Use; Geriatric Use; MONITORING; Baseline Monitoring; Ongoing Monitoring; Hematologic.

RenalLiver; VACCINATIONS; SUMMARY AND RECOMMENDATIONS; REFERENCES; 5. Chapter 5 -- Acitretin; KEY POINTS; INTRODUCTION; MECHANISM OF ACTION; EFFICACY; Monotherapy; Plaque psoriasis; Pustular psoriasis; Erythrodermic psoriasis; Combination Therapy; Acitretin and psoralen plus ultraviolet A; Acitretin and broadband ultraviolet B phototherapy; Acitretin and narrowband ultraviolet B phototherapy; Chemoprevention; SAFETY; Teratogenicity; Mucocutaneous; Musculoskeletal; Neurologic; Metabolic and Hepatic; Immunosuppression; Ophthalmologic; Psychiatric; PRECAUTIONS; Pregnancy Category X.

A brand-new title in the field of dermatology, Therapy for Severe Psoriasis provides the ultimate coverage of the treatment options available for today's most serious cases, including biologics and oral therapies. It features discussions of the newest drug therapies, recent FDA-approved biosimilars, and combination approaches to care, while an overview chapter was designed to aid those new to the field in understanding the nuances of difficult-to-treat subtypes of psoriasis. Comprehensive and focused, Therapy for Severe Psoriasis will be a welcome addition to the library of any dermatologist seeking in-depth information on the challenges of this condition.

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