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Cover; Title Page; Copyright Page; Contents; Contributors; Introduction and Overview; Chapter 1 -- A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis; Introduction; NO and NOx Prior to 1986; Ancient Human/NOx, NO Relationships; The Discovery of NO and 19th-Century Studies; 20th-Century NO Prior to 1986; 1986-88: Convergence of the Discovery of Endogenous NO in the Immune, Cardiovascular, and Nervous Systems; NO in the Immune System Prior to 1986-88; NO in the Cardiovascular System Prior to 1986-88; NO in the Nervous System Prior to 1986-88

The Convergence: 1986-88Conclusions; References; Chapter 2 -- An Integrated View of the Chemical Biology of NO, CO, H2S, and O2; Introduction; Nitric Oxide; Carbon Monoxide; Hydrogen Sulfide; Dioxygen; Superoxide; Hydrogen Peroxide; Hydroxyl Radical; Chemical Biology of NO, CO, H2S, and O2 Interactions; Interactions at Metal Centers: Heme Proteins; The Effect of O2 and Derived Species on the Chemical Biology of NO, CO, and H2S; Interaction of NO and H2S; Thiols/Thiol Proteins and NO, CO, O2, and H2S Chemical Biology; Summary; References

Chapter 3 -- Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art ReviewDetection of Nitric Oxide; Introduction; Detection of Nitrate and Nitrite; Griess Reaction; Chemiluminescence Detection of Nitrite/­Nitrate; Other Methods for Nitrite/Nitrate; Probes for NO Detection; Nitronyl Nitroxides; Iron Dithiocarbamates; Diaminofluorescein (DAF); S-Nitrosothiol Detection; Detection of Liberated Nitrogen Oxides From S-Nitrosothiols; Saville Reaction; Chemiluminescence; Detection of Protein S-Nitrosothiols; Biotin Switch Assay; Other Methods

Detection of Peroxynitrite Using Boronate-Based ProbesIntroduction; Oxidation of Boronates by Peroxynitrite and Other Biologically Relevant Oxidants; Free Radical Pathway for the Reaction Between Boronates and ONOO−; Real-Time Monitoring of ONOO− Formed In Situ in Cell-Free Systems; Differentiation Between Different Oxidants Using Boronic Probes; Detection of Peroxynitrite in Cellular ­Systems; Perspectives for In Vivo Detection of Peroxynitrite; Acknowledgment; References; Chapter 4 -- S-Nitrosothiols and Nitric Oxide Biology; Introduction; RSNO Biochemistry: How Do RSNOs Relate to NO

S-Nitrosothiol Levels and Targets In VivoSNO Antibody; RSNO Metabolism; RSNO Formation; Transnitrosation; Denitrosation; RSNO Transport; Emerging Modulators of RSNO: Hydrogen Sulfide and Reactive Sulfur Species; Biological Effects of RSNOs-Evidence and Interpretation; RSNO Therapeutics; RSNO as NO Donors; Summary; References; Chapter 5 -- Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology; Chemical Aspects of the NO/H2S Cross-Talk; Introduction; Basic Chemical Properties of Sulfide as Compared to NO

Bioactive Intermediates of the Reaction Between NO and Sulfide (and its Various Metabolites): S/N Hybrid Molecules and Poly...

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