Includes bibliographical references and index.

The search for progress and a new theory framework in cancer research / Marta Bertolaso and Bernhard Strauss -- Cancer as a system : hard lessons from physics, and a way forward / Thea J. Newman -- The logic of cancer treatment : Why it is so hard to cure cancer / Sui Huang -- The cell attractor concept as a tool to advance our understanding of cancer / Ingemar Ernberg -- Adaptation of molecular interaction networks in cancer cells / Peter Csermely -- The role of genomic dark-matter in cancer--using AI to shine a light on it : why cancer genes are not the whole story / Kahn Rhrissorrakrai and Laxmi Parida -- Darwinism, not mutationalism, for new cancer therapies / Jacob Scott, David Basanta, and Andriy Marusyk -- Cancer as a reversion to an ancestral phenotype / Kimberly J. Bussey and Paul C. W. Davies -- Time and timing in oncology : What therapy scheduling can teach us about cancer biology / Larry Norton -- Tissue tension modulates metabolism and chromatin organization to promote malignancy / Roger Oria, Dhruv Thakar, and Valerie M. Weaver -- Cancer Metabolism & Therapeutic Perspectives : Exploiting Acidic, Nutritional and Oxidative stresses / Maša Ždralević and Jacques Pouysségur -- Corrupted vascular tumor niches confer aggressiveness and chemoresistance to neoplastic cells / Luca V. Capelli, Liron Yoffe, and Giorgio Inghirami -- Metastasis as a tug of war between cell autonomy and microenvironmental control : Re-addressing unresolved questions in cancer metastasis / Courtney König and Christoph A. Klein -- Niche re-construction to revert or transcend the cancer state / Emmy W. Verschuren.

"Steps toward an explanatory paradigm for cancer that integrates its different levels of organization (molecular, genetic, etc.) and also integrates theoretical and experimental biology with oncology"--