TY - BOOK AU - Selkoe,Dennis J. AU - Triller,Antoine AU - Christen,Yves ED - SpringerLink (Online service) TI - Synaptic Plasticity and the Mechanism of Alzheimer's Disease T2 - Research and Perspectives in Alzheimer's Disease, SN - 9783540763307 AV - RC321-580 U1 - 612.8 23 PY - 2008/// CY - Berlin, Heidelberg PB - Springer Berlin Heidelberg KW - Medicine KW - Human physiology KW - Neurosciences KW - Biomedicine KW - Human Physiology KW - Electronic books KW - local N1 - Permanence of the Synapse and Molecular Instability -- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity -- Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo -- Synapse Loss, Synaptic Plasticity and the Postsynaptic Density -- Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity -- Quantitative Neuropathology in Alzheimer’s Mouse Models -- Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States -- Soluble Oligomers of the Amyloid ?-Protein: Impair Synaptic Plasticity and Behavior -- Why Alzheimer’s is a Disease of Memory: Synaptic Targeting by Pathogenic A? Oligomers (ADDLs) -- Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-? Levels -- A?-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP) -- Long-Term Potentiation and A?: Targeting A? Species, Cellular Mechanisms and Putative Receptors -- Genes, Synapses and Autism Spectrum Disorders N2 - (will follow) UR - http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-540-76330-7 ER -