TY  - BOOK
AU  - Minarovits,Janos
AU  - Niller,Hans Helmut
ED  - SpringerLink (Online service)
TI  - Patho-Epigenetics of Infectious Disease
T2  - Advances in Experimental Medicine and Biology,
SN  - 9783319247380
AV  - QH434 
U1  - 579.135 23
PY  - 2016///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Life sciences
KW  - Medical microbiology
KW  - Molecular biology
KW  - Virology
KW  - Infectious diseases
KW  - Microbial genetics
KW  - Microbial genomics
KW  - Life Sciences
KW  - Microbial Genetics and Genomics
KW  - Infectious Diseases
KW  - Molecular Medicine
KW  - Medical Microbiology
KW  - Electronic books
KW  - local
N2  - Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment
UR  - http://ezproxy.alfaisal.edu/login?url=http://dx.doi.org/10.1007/978-3-319-24738-0
ER  -