Cover -- Copyright Page -- Dedication Page -- Contents -- Contributors -- Acknowledgment -- Chapter 1: Epilepsy in the Elderly: Scope of the Problem -- I. Introduction -- II. Known Knowns -- A. Incidence and Prevalence of Epilepsy Is Higher in the Community-Dwelling Elderly Than in Younger Adults or Children -- B. Prevalence and Incidence of Epilepsy Is Higher Among Nursing Home Residents Than Community-Dwelling Elderly -- C. Retirement Age of 65 Is a Political Decision, Not Related to Medical Condition -- D. The Elderly Are Not a Homogeneous Group -- E. Patterns of AED Use Differ Markedly Between Countries and Between Community-Dwelling and Nursing Home Elderly -- F. In Nursing Homes, the Young-Old are More Likely to Use an AED than the Old-Old -- G. Causes of Epilepsy in the Elderly -- H. Many Seizures in the Elderly are not Epileptic -- I. AED Pharmacology Is Different in the Elderly -- J. Choosing AEDs for an Elderly Person Is Difficult -- K. Drug Interactions With Non-AEDs Are a Major Problem -- III. Known Unknowns -- IV. Unknown Unknowns -- V. Unknown Knowns -- A. The "Therapeutic" Range of Total Phenytoin is 10-20 mg/liter -- B. AED Levels Are Stable Over Time With Constant Doses -- VI. Conclusion -- References -- Chapter 2: Animal Models in Gerontology Research -- I. Animal Models in Aging Research: Considerations for Experimental Design -- II. The Age Factor -- III. Genetic Background -- IV. Choice of Strain -- V. Environmental Influences -- VI. Genomic Manipulations -- VII. Resources -- References -- Chapter 3: Animal Models of Geriatric Epilepsy -- I. Introduction -- II. Mouse Models -- A. Senescence-Accelerated Mouse -- B. Cacnb4 (lh) Mouse -- C. MTIII( -/- ) Mouse -- D. El Mouse -- E. DBA Mouse -- F. Acute Seizure Models in Common Strains -- III. Gerbil Model -- IV. Rat Models -- A. Acute Seizure Models -- B. Lesion Models -- C. Chronic Epilepsy Models -- V. Conclusions -- References -- Chapter 4: Life and Death of Neurons in The Aging Cerebral Cortex -- I. Introduction -- II. Cortical Circuitry and Alzheimer's Disease -- A. Overview -- B. Hippocampal Pathology in AD -- C. Neocortical Pathology in AD -- D. Neurofilament Protein Is a Marker of Neuronal Vulnerability in AD -- E. Summary: AD and Cortical Circuitry -- III. AAMI: Functional Decline Without Neuron Loss -- A. Introduction -- B. The Aging Cerebral Cortex: Nonhuman Primate Studies -- IV. Interactions Between Neural and Endocrine Senescence -- V. Conclusions -- Acknowledgments -- References -- Chapter 5: An In Vitro model of Stroke-Induced Epilepsy: Elucidation of the Roles of Glutamate and Calcium in the Induction and Maintenance of Stroke-Induced Epileptogenesis -- I. Introduction -- II. Role of Glutamate in the Pathophysiology of Stroke -- III. Developing an In Vitro Model of Glutamate Injury That Causes a Mixed Population of Injured and Dead Neurons in Preparations of Hippocampal Neurons in Culture -- IV. Development of SREDs in Neurons Surviving Injury -- V. Neuronal Networks Di.
Discusses all aspects of epilepsy in aging patients.
9780080489254 0080489257 0123740185 9780123740182
013771828 Uk
Epilepsy in old age. Neurobiology. MEDICAL--Geriatrics. MEDICAL--Nursing--Gerontology. Epilepsy in old age. Neurobiology.