Introduction -- Gross Anatomy of the Peripheral Nervous System -- Microscopic Anatomy of the Peripheral Nervous System -- Channel Function in Mammalian Axons and Support Cells -- Nerve Excitability Measures: Biophysical Basis and Use in the Investigation of Peripheral Nerve Disease -- The Muscle Spindle -- The Golgi Tendon Organ -- The Peripheral Sensory Nervous System: Dorsal Root Ganglion Neurons -- The Pupil -- Neural Control of Cardiac Function -- Neurobiology of Autonomic Ganglia -- Neurobiology of the Enteric Nervous System -- Autonomic and Somatic Systems to the Anorectum and Pelvic Floor -- Autonomic Systems to the Urinary Bladder and Sexual Organs -- Sympathetic Nerves and Control of Blood Vessels to Human Limbs -- Molecular Signaling in Schwann Cell Development -- Neurotrophic Factors in the Peripheral Nervous System -- Axonal Transport: Properties, Mechanisms, and Role in Nerve Disease -- Myelination -- The Control of Axonal Caliber -- Guidance of Axons to Targets in Development and in Disease -- Aging in the Peripheral Nervous System -- Oxidative Stress and Excitatory Neurotoxins in Neuropathy -- Transgenic Models of Nerve Degeneration -- Introduction to Immune Reactions in the Peripheral Nervous System -- Peripheral Nerve Antigens -- Experimental Autoimmune Neuritis -- Experimental Autoimmune Neuritis -- Principles of Immunotherapy -- Blood-Nerve Interface and Endoneurial Homeostasis -- Nerve Blood Flow and Microenvironment -- Pathology of Peripheral Neuron Cell Bodies -- Pathologic Alterations of Nerves -- Diseases of the Neuromuscular Junction -- Pathology and Quantitation of Cutaneous Innervation -- Nerve Conduction and Needle Electromyography -- Nerve Tests Expressed as Percentiles, Normal Deviates, and Composite Scores -- Single-Fiber Electromyography and Other Electrophysiologic Techniques for the Study of the Motor Unit -- Single-Unit Recordings of Afferent Human Peripheral Nerves by Microneurography -- Compound Action Potentials of Sural Nerve in Vitro in Peripheral Neuropathy -- Quantitating Overall Neuropathic Symptoms, Impairments, and Outcomes -- Health Outcomes and Quality of Life -- Quantitative Sensation Testing -- Quantitative Muscle Strength Assessment -- Quantitation of Autonomic Impairment -- Clinical Patterns of Peripheral Neuropathy -- Differential Diagnosis of Polyneuropathy -- Epidemiologic Approaches to Peripheral Neuropathy -- Diseases of the Third, Fourth, and Sixth Cranial Nerves -- Diseases of the Fifth Cranial Nerve -- Diseases of the Seventh Cranial Nerve -- Diseases of the Eighth Cranial Nerve -- Diseases of the Ninth, Tenth, Eleventh, and Twelfth Cranial Nerves -- The Peripheral Nerve Involvement of Spinal Cord, Spinal Roots, and Meningeal Disease -- Diseases of Spinal Roots -- Brachial Plexus Lesions -- Lumbosacral Plexus Lesions -- Mechanisms of Acute and Chronic Compression Neuropathy -- Mechanisms of Repair after Traumatic Injury -- Median Neuropathy -- Upper Limb Neuropathies: Long Thoracic (Nerve to the Serratus Anterior), Suprascapular, Axillary, Musculocutaneous, Radial, Ulnar, and Medial Antebrachial Cutaneous -- Mononeuropathies of the Lower Limb. Operating on Peripheral Nerves -- Sporadic Motor Neuron Degeneration -- Mendelian and Mitochondrial Inheritance, Gene Identification, and Clinical Testing -- Transgenic Models of Inherited Neuropathy -- Transgenic Animal Models of Amyotrophic Lateral Sclerosis -- Inherited Motor Neuron Degeneration -- Inherited Neuronal Atrophy and Degeneration Predominantly of Lower Motor Neurons * -- Hereditary Motor and Sensory Neuropathies: An Overview of Clinical, Genetic, Electrophysiologic, and Pathologic Features -- Hereditary Motor and Sensory Neuropathies Involving Altered Dosage or Mutation of PMP22: The CMT1A Duplication and HNPP Deletion -- Hereditary Motor and Sensory Neuropathies Related to MPZ (P o) Mutations -- Hereditary Motor and Sensory Neuropathy Related to Early Growth Response 2 (EGR2) Gene -- HMSN II (CMT2) and Miscellaneous Inherited System Atrophies of Nerve Axon: Clinical-Molecular Genetic Correlates -- Hereditary Brachial Plexus Neuropathy -- Autosomal Recessive Hereditary Motor and Sensory Neuropathies -- X-linked Charcot-Marie-Tooth Disease -- Multiple Endocrine Neoplasia, Type 2B -- HSANs: Clinical Features, Pathologic Classification, and Molecular Genetics -- Lysosomal and Peroxisomal Disorders -- Porphyric Neuropathy -- Fabry's Disease -- Tangier Disease and Neuropathy -- Hereditary Amyloid Neuropathy -- Peripheral Nerve Diseases Associated with Mitochondrial Respiratory Chain Dysfunction -- Diabetic Neuropathies -- Radiculoplexus Neuropathies: Diabetic and Nondiabetic Varieties -- Neuropathies Associated with Renal Failure, Hepatic Disorders, Chronic Respiratory Disease, and Critical Illness -- Neuropathy in Diseases of the Thyroid and Pituitary Glands -- Polyneuropathy Caused by Nutritional and Vitamin Deficiency -- Tropical Myeloneuropathies -- Leprosy -- Lyme Disease -- Herpesvirus Infection and Peripheral Neuropathy -- Peripheral Neuropathies in Human Immunodeficiency Virus Infection -- Diphtheritic Polyneuropathy -- Parasitic Infections of the Peripheral Nervous System -- Polyneuropathies and Antibodies to Nerve Components -- The Guillain-Barré Syndromes -- Chronic Inflammatory Demyelinating Polyradiculoneuropathy -- Neuropathy Associated with the Monoclonal Gammopathies -- Multifocal Motor Neuropathy and Conduction Block -- Immune Brachial Plexus Neuropathy -- Nonmalignant Inflammatory Sensory Polyganglionopathy -- Cryptogenic Sensory Polyneuropathy -- Neuropathies with Systemic Vasculitis -- Microvasculitis -- Sarcoid Neuropathy -- Amyloidosis and Neuropathy -- POEMS Syndrome (Osteosclerotic Myeloma) -- Paraneoplastic Neuropathy -- Peripheral Neuropathy Associated with Lymphoma, Leukemia, and Myeloproliferative Disorders -- Human Toxic Neuropathy Caused by Industrial Agents -- Metal Neuropathy -- Neuropathy Caused by Drugs -- Tumors and Tumor-like Conditions of Peripheral Nerve -- Management of Patients with Acute Neuromuscular Disease in the Intensive Care Unit -- Rehabilitation Management of Neuropathies -- Mechanisms and Pharmacologic Management of Neuropathic Pain -- Management of Autonomic Failure -- Treatment of Cardiovascular Autonomic Failure -- Management of Gut Dysmotility -- Peripheral Neuropathies in Infants and Children: Polyneuropathies, Mononeuropathies, Plexopathies, and Radiculopathies.
Edited by internationally acclaimed experts in the field, this authoritative 2-volume Gold Standard comprehensively covers the neurobiology and diseases of the peripheral nervous system. It encompasses neurobiology, clinical neurophysiology, molecular genetics, and clinical diagnosis and management. The 4th Edition has been rewritten and updated to provide a fresh account of all subjects, with an emphasis on new information about cell biology, genetics, proteomics, clinical manifestations, and new treatments. And, a user-friendly organization allows readers to quickly find specific information, or access more in-depth coverage when needed. Provides authoritative, in-depth information on neurobiology and diseases of the peripheral nervous system. Presents complete coverage of development - anatomy - physiology - pharmacology -special testing (nerve conduction and EMG), autonomic testing, and testing of impairment and disability - and the diagnosis, management, and outcomes for peripheral neuropathies. Includes information on epidemiologic survey and pharmaceutical industry trials, with coverage of the complications of diabetes mellitus and other metabolic diseases.
9781437713473 1437713475
Nerves, Peripheral--Diseases. Nerves, Peripheral--Diseases. Neuropathie. Doenças do sistema nervoso periférico. Nervos periféricos (patologia) Peripheral Nervous System Diseases [MESH] Peripheral Nerves--pathology [MESH]