TY  - BOOK
AU  - Aschner,Michael
AU  - Costa,Lucio G.
ED  - ScienceDirect eBooks.
TI  - Environmental factors in neurodevelopmental and neurodegenerative disorders
SN  - 9780128004074
AV  - QP363.5 
PY  - 2015///]
CY  - Amsterdam
PB  - Academic Press, Elsevier
KW  - Developmental neurobiology
KW  - Nervous system
KW  - Degeneration
KW  - MEDICAL
KW  - Physiology
KW  - bisacsh
KW  - SCIENCE
KW  - Life Sciences
KW  - Human Anatomy & Physiology
KW  - fast
KW  - Neurodegenerative Diseases
KW  - etiology
KW  - Neurodevelopmental Disorders
KW  - Electronic books
KW  - local
N1  - Includes bibliographical references and index; Front Cover; Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders; Copyright; Contents; Preface; Foreword; Contributors; Section-01 -- Neurodevelopmental Disorders ; CHAPTER 1 -- OVERVIEW OF THE ROLE OF ENVIRONMENTAL FACTORS IN NEURODEVELOPMENTAL DISORDERS; INTRODUCTION; EVIDENCE IMPLICATING ENVIRONMENTAL FACTORS; FOR NEURODEVELOPMENTAL DISORDERS; MECHANISMS BY WHICH ENVIRONMENTAL FACTORS INFLUENCE RISK OF NEURODEVELOPMENTAL DISORDERS; CONCLUSIONS; References; Chapter 2 -- Genetic Factors in Environmentally Induced Disease; INTRODUCTION; PARKINSON'S DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ALZHEIMER'S DISEASE; CONCLUSIONS AND FUTURE DIRECTIONS; References; Chapter 3 -- Fetal Alcohol Spectrum Disorders: Effects and Mechanisms of Ethanol on the Developing Brain; INTRODUCTION; FETAL ALCOHOL SPECTRUM DISORDERS (FASD); FASD PREVALENCE; NEUROBEHAVIORAL DEFICITS IN FASD; FASD AND BRAIN STRUCTURES; ANIMAL MODELS FOR FASD; MECHANISMS INVOLVED IN FASD; EXPERIMENTAL TREATMENTS FOR FASD; Acknowledgments; References; Chapter 4 -- Prenatal Infection: Setting the Course of Brain Aging and Alzheimer's Disease?; INTRODUCTION; WHAT CHARACTERIZES ALZHEIMER'S DISEASE?; ALZHEIMER'S DISEASE; BASIC CELLULAR FUNCTIONS; FROM AXONAL VARICOSITIES TO AXONAL DEGENERATION; CONCLUSIONS; References; Chapter 5 -- Neurobehavioral Effects of Air Pollution in Children; INTRODUCTION; EVIDENCE FROM EPIDEMIOLOGICAL RESEARCH; EVIDENCE FROM ANIMAL RESEARCH; BIOLOGICAL PATHWAYS; EVALUATION OF THE EVIDENCE AND FUTURE RESEARCH DIRECTIONS; CONCLUSIONS; References; Chapter 6 -- The Role of Methylmercury Exposure in Neurodevelopmental and Neurodegenerative Disorders; INTRODUCTION; FETAL MINAMATA DISEASE AND ASSOCIATED DISORDERS; Environmental epidemiology studies of low-level mehg exposure: improving measurements and methods of maternal fish consumption for childhood outcomes; insights on neurobehavioral effects of mehg from animal model studies; cross-species comparisons of mehg neurodevelopmental effects; mechanisms underlying mehg-mediated neurotoxicity; energetics, altered ca2+ homeostasis, and production of reactive oxygen species; effects of mehg on microtubules as a mechanism underlying developmental neuropathology; effects of mehg on astrocytes and microglia; neuronal signaling; DELAYED NEUROTOXICITY, NEURODEGENERATIVE DISEASE, AND INTERGENERATIONAL EFFECTS; THE SOCIETAL AND HUMAN COSTS OF MEHG EXPOSURE; Acknowledgments; References; Chapter 7 -- Developmental Exposure to Lead: Overview and Integration of Neurobehavioral Consequences and Mediation; INTRODUCTION AND FOCUS; AND OCCUPATIONAL CONTAMINANT; THE PERSISTENT QUESTION OF WHETHER ELEVATED LEAD EXPOSURE REDUCES IQ; CHANGES IN LEARNING; AS BEHAVIORAL MECHANISMS OF LEAD-INDUCED LEARNING AND IQ DEFICITS?; PERSISTENCE OF DEVELOPMENTAL LEAD NEUROTOXICITY
N2  - Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit
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ER  -