TY  - BOOK
AU  - Nohmi,Takehiko
AU  - Fukushima,Shoji
ED  - ScienceDirect eBooks.
TI  - Thresholds of genotoxic carcinogens: from mechanisms to regulation 
SN  - 9780128018033
AV  - RA1224.3 
PY  - 2016///
CY  - London, UK
PB  - Academic Press is an imprint of Elsevier
KW  - Genetic toxicology
KW  - Carcinogenesis
KW  - HEALTH & FITNESS / Diseases / General
KW  - bisacsh
KW  - MEDICAL / Clinical Medicine
KW  - MEDICAL / Diseases
KW  - MEDICAL / Evidence-Based Medicine
KW  - MEDICAL / Internal Medicine
KW  - fast
KW  - Electronic books
KW  - local
N1  - Includes index; Title page; Table of Contents; Copyright; List of Contributors; Preface; Chapter 1. Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis; Abstract; Introduction; Qualitative and Quantitative Analyses on Low-Dose Carcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Rat Liver; Qualitative and Quantitative Analyses on Low-Dose Hepatocarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in the Rat Liver; Qualitative and Quantitative Analysis on Low-Dose Hepatocarcinogenicity of N-nitrosodiethylamine in the Rat LiverDiscussion; References; Chapter 2. Thresholds for Hepatocarcinogenicity of DNA-Reactive Compounds; Abstract; Introduction; Dose-Effect Studies of Initiation of Liver Carcinogenesis; Conclusions; Relevance to Humans; References; Chapter 3. Interaction of Low-Dose Radiation and Chemicals in Cancer Risk; Abstract; Epidemiological Analysis of Cancer Risk; Interaction of Radiation and Other Carcinogens; Data From Animal Experiments; Conclusion; Acknowledgments; References; Chapter 4. Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA SynthesisAbstract; Introduction; Challenges in Identification of Genotoxicity of Chemicals; Possible Mechanisms Underlying Genotoxic Thresholds; Significance of DNA Repair Mechanisms in the Suppression of Mutagenesis and Tumorigenesis in Mammals; TLS as a Critical Factor for Mutagenesis; Future Perspectives; Acknowledgments; References; Chapter 5. DNA Repair and Its Influence on Points of Departure for Alkylating Agent Genotoxicity; Abstract; Introduction; The Paradigm Shift in Response to Low Doses of Alkylating AgentsAlkylating Agent Mechanism of Action; DNA Repair of Alkyl Adducts: Potential Influences on PoDs; Mechanistic Evidence Supporting a PoD for EMS; Mechanistic Evidence Supporting a PoD for ENU; Mechanistic Evidence Supporting a PoD for MMS; Mechanistic Evidence Supporting a PoD for MNU; Concluding Remarks; References; Chapter 6. The Role of Endogenous Versus Exogenous DNA Damage in Risk Assessment; Abstract; Introduction; Aldehydes; Alkylating Agents; Oxidative Stress; Ionizing Radiation; Quantifying Complex Dose-Response Relationships to Support Risk AssessmentsConclusion; References; Chapter 7. Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals; Abstract; Introduction; Genotoxic and Nongenotoxic Carcinogens; Thresholds of Chemical Genotoxicity; Risk Management for Genotoxic Carcinogens; Risk Assessment and Control of Genotoxic Impurities in Pharmaceuticals; Conclusion; References; Chapter 8. Practical Thresholds in the Derivation of Occupational Exposure Limits (OELs) for Carcinogens; Abstract; Introduction
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ER  -