Executive functions in health and disease /
edited by Elkhonon Goldberg.
- [2017]
- 1 online resource.
Includes bibliographical references and index.
Title page; Table of Contents; Copyright; List of Contributors; Preface; Part I: Executive Functions in Health; Chapter 1. Prefrontal Executive Functions Predict and Preadapt; Abstract; Introduction; The PA Cycle; Executive Attention; Working Memory; Decision-Making; References; Chapter 2. The Cellular Mechanisms of Executive Functions and Working Memory: Relevance to Mental Disorders; Abstract; Introduction; Topography of PFC and Its Relevance to Neuropsychiatric Pathology; Dorsolateral Prefrontal Cortex; Physiology and Microcircuitry of Working Memory Molecular Regulation of dlPFC Representational CircuitsMechanisms That Weaken dlPFC Network Connections; Mechanisms That Strengthen dlPFC Network Connections; Catecholamine Modulation of Mechanisms That Weaken PFC Activity During Uncontrollable Stress; Alpha-2A Noradrenergic Influence: Successful Translation Modulation of Mechanisms That Both Weaken and Strengthen Firing; Conclusion; Acknowledgments; References; Chapter 3. Gene Expression in the Frontal Lobe; Abstract; Introduction; Development of Cerebral Neocortex and Circuitry in the Human Fetal Brain Methodological Limitations of Human Transcriptomic StudiesGene Expression in the Cerebral Cortex of the Human Brain; Conclusion; References; Chapter 4. A Functional Network Perspective on the Role of the Frontal Lobes in Executive Cognition; Abstract; The Classic Approach to Functional Brain Mapping; Probing the Functional Heterogeneity of the Human PFC Using an FMRI Optimized Intradimensional-Extradimensional Switching Paradigm; Limitations of Modular Perspectives; Response Inhibition and the Inferior Frontal Gyrus; A Broader Role for the RIFG in Cognition? Voodoo Neuroimaging Validations of Cognitive ConstructsA General Intelligence System Within the Frontal and Parietal Cortices?; A Network-Based Fractionation of Human Intelligence; Network-Oriented Cognitive Constructs; Network Dynamics During Relational Integration; Combining Modular and Network Perspectives; Functional Network Markers of Neuropathology in Retired NFL Players; Conclusion; References; Chapter 5. Neural Network Models of Human Executive Function and Decision Making; Abstract; Introduction: What Are Neural Networks?; Models of Decision Making Models of Sequence Learning and Working MemoryModels of Overcoming Habitual Responses; Models of General Cognitive Control; General Discussion; References; Chapter 6. Crucial Role of the Prefrontal Cortex in Conscious Perception; Abstract; Early Neuroimaging Evidence of Prefrontal Cortex's Involvement in Conscious Perception; The "No-Report" Argument Against PFC's Role in Consciousness; Responses to the No-Report Argument; The Argument Based on Lesion Studies; Responses to the "Lesion" Argument; Why Do PFC Lesions Produce Such Subtle Effects?; Implications for Theories of Consciousness
Executive Functions in Health and Disease provides a comprehensive review of both healthy and disordered executive function. It discusses what executive functions are, what parts of the brain are involved, what happens when they go awry in cases of dementia, ADHD, psychiatric disorders, traumatic injury, developmental disorders, cutting edge methods for studying executive functions and therapies for treating executive function disorders. It will appeal to neuropsychologists, clinical psychologists, neuroscientists and researchers in cognitive psychology.