TY  - BOOK
AU  - Deisenhammer,Florian
AU  - Teunissen,Charlotte E.
AU  - Tumani,Hayrettin
ED  - ScienceDirect eBooks.
TI  - Cerebrospinal fluid in neurologic disorders
T2  - Handbook of clinical neurology
SN  - 9780128043240
AV  - QP375 
PY  - 2017///
KW  - Cerebrospinal fluid
KW  - MEDICAL / Physiology
KW  - bisacsh
KW  - SCIENCE / Life Sciences / Human Anatomy & Physiology
KW  - fast
KW  - Cerebrospinal Fluid
KW  - Nervous System Diseases
KW  - Electronic books
KW  - local
N1  - Includes bibliographical references and index; ""Front Cover""; ""Cerebrospinal Fluid in Neurologic Disorders""; ""Copyright""; ""Available titles""; ""Foreword""; ""Preface""; ""Contributors""; ""Contents""; ""Section I: General aspects""; ""Chapter 1: The use of cerebrospinal fluid in biomarker studies""; ""Introduction""; ""Definition of biomarkers and type of biomarkers""; ""Physiology of CSF""; ""Biomarker subtypes""; ""Proteins""; ""Metabolites""; ""Cell-free DNA""; ""Messenger RNA/micro RNA""; ""Exosomes""; ""Sample collection and biobanking: preanalytic variation""; ""Patient-related factors""; ""Age and sex""; ""Genetic background""""Circadian rhythm""; ""Coffee, chocolate, smoking, and alcohol consumption""; ""Preanalytic procedures""; ""Lumbar puncture""; ""Risk factors and recommendations in performing an LP""; ""Type of tube""; ""Evaporation""; ""Centrifugation speed and temperature""; ""Quality assessment of collection procedures""; ""Analytic aspects in CSF biomarker studies: assay development and validation""; ""Technical analysis: optimizing immunoassay validation and development of novel biomarkers""; ""Quality assessment of analytic procedures""; ""Matrix reference material""; ""Clinical study design in CSF biomarker studies""""Discussion: how to increase the number of novel biomarkers?""; ""Concluding remarks""; ""References""; ""Chapter 2: The cerebrospinal fluid and barriers -- anatomic and physiologic considerations""; ""Introduction""; ""Physiology of CSF: what is CSF good for, where does it come from, how is it circulating, where does it go?""; ""Biologic function""; ""Sites of production""; ""Circulation""; ""Absorption""; ""Transfer mechanisms""; ""Barriers of the CNS compartment: what are the differences between BBB and BCB?""; ""The blood-brain barrier""; ""The blood-CSF barrier""""Anatomy of CSF spaces: which brain areas are reflected by CSF analysis?""; ""CSF constituents: which factors influence their concentration and what is their implication for CSF analysis?""; ""Circadian changes""; ""Site of sampling (lumbar vs. ventricular CSF)""; ""Volume of CSF sampled""; ""Physical activity and head movement""; ""Clearance via specific transporters""; ""Surgical intervention""; ""Concluding remarks""; ""References""; ""Chapter 3: More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue""; ""The concept of volume transmission""""The functional influence of CSF on brain cells""; ""Adult neurogenesis""; ""CSF-contacting neurons""; ""The functional contribution of CSF in pathologic CNS conditions""; ""Traumatic brain injury (TBI)""; ""Anti-NMDAR encephalopathy""; ""Brain aging and dementia""; ""Summary""; ""Abbreviations""; ""References""; ""Chapter 4: Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models""; ""Introduction""; ""CSF and brain interstitial fluid""
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ER  -