Pathophysiology of signs and symptoms of coma -- Examination of the comatose patient -- Structural causes of stupor and coma -- Specific causes of structural coma -- Metabolic and diffuse encephalopathies: disruption of the internal milieu -- Psychogenic unresponsiveness -- Initial management of patients with stupor and coma -- Management of frequently encountered causes of unconsciousness -- Prognosis in coma and related disorders of consciousness and mechanisms underlying outcomes -- Brain death.