This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. Key features: reactive species as intracellular messengers; redox regulation of cellular responses; and clinical implications of redox signaling and antioxidant therapy.

Reactive Species as Intracellular Messengers: -- L.-O. Klotz, K. Briviba, and H. Sies, Signalling by Singlet Oxygen in Biological Systems. -- D.R. Crawford, T. Suzuki, and K.J.A. Davies, Oxidant-modulated Gene Expression. -- H.H. Hassanain and P.J. Goldschmidt-Clermont, RAC, Superoxide, and Signal Transduction. -- S.K. Koliwad, A.K. Brzezinska, and S.J. Elliott, Redox Regulation of Ion Channels. -- J. Giron-Calle and H.J. Forman, Cell Ca²⁺ in Signal Transduction: Modulation in Oxidative Stress. -- G.L. Schieven, Introduction of Protein Tyrosine Phosphorylation by Oxidative Stress and its Implications. -- A.A. Deora and H.M. Lander, Regulation of Signal Transduction and Gene Expression by Reactive Nitrogen Species. -- Redox Sensitive Molecular Processes and Cellular Responses: -- P.A. Baeuerle, Reactive Oxygen Species as Costimulatory Signals of Cytokine-Induced NFkappaB Activation Pathways. -- T. Okamoto, T. Tetsuka, and T. Kawabe, Redox Regulation of Nuclear Factor kappa B. -- C.K. Sen, Oxidants and Antioxidants in Aptosis: Role of Bcl-2. -- V. Goossens, K. De Vos, D. Vercammen, M. Steemans, K. Vancompernolle, W. Fiers, P. Vandenabeele, and J. Grooten, Role of Reactive Oxygen Species in TNF Toxicity. -- S. Roy, C.K. Sen, A. Gozin, V. Andrieu, and C. Pasquier, Redox Regulation of Cell Adhesion Processes. -- H. Masutani, M. Ueno, S. Ueda, and J. Yodoi, Role of Thioredoxin and Redox Regulation in Oxidative Stress Response and Signalling. -- A.H. Schönthal, S. Mueller, and E. Cadenas, Redox Regulation of p21, Role of Reactive Oxygen and Nitrogen Species in Cell Cycle Progression. -- Clinical Implications of Redox Signaling and Antioxidant Therapy: -- H. Viita and S. Yl̃-Hertuala, Effect of Lipoxygenases on Gene Expression in Mammalian Cells. -- A. Azzi, Tocopherol in the Pathogenesis of Atherosclerosis: One Molecule, Several Functions. -- D.-Y. Jin and K.-T. Jeang, Peroxiredoxins in Cell Signaling and HIV Infection. -- J.S. Bertram, T. King, L. Fukishima, and F. Khachik, Enhanced Activity of an Oxidation Product of Lycopene Found in Tomato Products and Human Serum Relevant to Cancer Prevention. -- C. Bladier, J.B. de Haan, and I. Kola, Antioxidant Genes and Reactive Oxygen Species in Down's Syndrome. -- B.S. Kristal and B.P. Yu, Oxidant-mediated Repression of mtDNA Transcription. -- Y. Kajimoto, Y. Yamasaki, T. Matsuoka, H. Kaneto, and M. Hori, Suppression of the Insulin Gene Promoter Activity by Oxidative Stress. -- N. Maulik and D.K. Das, Redox Regulation of Ischemic Adaptation. -- W.C. Orr and R.S. Sohal, Oxidative Stress as a Governing Factor in Physiological Aging. -- W. Dröge, V. Hack, R. Breitkreutz, E. Holm, S. Holm, and R. Kinscherf, Antioxidants in Senescence and Wasting. -- Subject Index.

Includes bibliographical references and index.

Signaling by singlet oxygen in biological systems / Lars-Oliver Klotz, Karlis Briviba, and Helmut Sies -- Redox regulation of gene expression / Dana R. Crawford, Toshihide Suzuki, and Kelvin J.A. Davies -- Rac, superoxide, and signal transduction / Hamdy H. Hassanain and Pascal J. Goldschmidt-Clermont -- Redox regulation of ion channels / Suneil K. Koliwad, Anna K. Brzezinska, and Stephen J. Elliot -- Cell Ca² in signal transduction : modulation in oxidative stress / Julio Girón-Calle and Henry Jay Forman -- Induction of protein tyrosine phosphorylation by oxidative stress and its implications / Gary L. Schieven -- Regulation of signal transduction and gene expression by reactive nitrogen species / Ami A. Deora and Harry M. Lander -- Reactive oxygen species as costimulatory signals of cytokine-induced NF-[kappa]B activation pathways / Patrick A. Baeuerle -- Redox regulation of NF-[kappa]B / Takashi Okamoto [and others] -- Oxidants and antioxidants in apoptosis : role of Bcl-2 / Chandan K. Sen -- Role of reactive oxygen species in tumor necrosis factor toxicity / Vera Goossens [and others] -- Redox regulation of cell adhesion processes / Sashwati Roy [and others] -- Role of thioredoxin and redox regulation in oxidative stress response and signaling / Hiroshi Masutani [and others] -- Redox regulation of p21, role of reactive oxygen and nitrogen species in cell cycle progression / Axel H. Schönthal, Sebastian Mueller, and Enrique Cadenas -- Effects of lipoxygenases on gene expression in mammalian cells / Helena Vitta and Seppo Ylä-Herttuala -- [alpha]-tocopherol in the pathogenesis of atherosclerosis : one molecule, several functions / Angelo Azzi -- Peroxiredoxins in cell signaling and HIV infection / Dong-Yan Jin and Kaun-The Jeang -- Enhanced activity of an oxidation product of lycopene found in tomato products and human serum relevant to cancer prevention / John S. Bertram [and others] Antioxidant genes and reactive oxygen species in Down's syndrome / Cécile Bladier, Judy B. de Haan, and Ismail Kola -- Oxidant-mediated repression of mitochondrial DNA transcription / Bruce S. Kristal and Byung P. Yu -- Suppression of insulin gene promoter activity by oxidative stress / Yoshitaka Kajimoto [and others] -- Redox regulation of ischemic adaptation / Nilanjana Maulik and Dipak K. Das -- Oxidative stress as a governing factor in physiological aging / William C. Orr and Rajindar S. Sohal -- Antioxidants in senescence and wasting / Wulf Dröge [and others].

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