Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology.

Introduction. S. Penman, B.J. Blencowe, and J.A. Nickerson, The Nuclear Matrix: Past and Present. Nuclear Matrix Structure and Function: R. Berezney, The Nuclear Matrix: Mapping Genomic Organization and Function in the Cell Nucleus. K.A. Mattern, R. van Driel, and L. de Jong, Composition and Structure of the Internal Nuclear Matrix. T. Kohwi-Shigematsu and Y. Kohwi, High Unwinding Capability of Matrix Attachment Regions and ATC-Sequence Context-Specific MAR-Binding Proteins. R.C. Bird, The Cyclin/Cyclin-Dependent Kinase Complex: Regulation of Cell Cycle Progression and Nuclear Disassembly. Chromatin Structure and Transcritpion Complexes: G.S. Stein, A.J. van Wijnen, J. Stein, J.B. Lian, and M. Montecino, Nuclear Architecture in Developmental Transcriptional Control of Cell Growth and Tissue-Specific Genes. D.G. Wansink, L. de Jong, and R. van Driel, Transcription by RNA Polymerase II and Nuclear Architecture. Nuclear mRNP Complexes: S.A. Amero and K.C. Sorensen, Protein Disposition on Nascent Pre-mRNA Transcripts. Chapter References. Subject Index.

Includes bibliographical references and index.

The Nuclear matrix: past and present / Sheldon Penman, Benjamin J. Blencowe, and Jeffrey A. Nickerson -- The Nuclear matrix: mapping genomic organization and function in the cell nucleus / Ronald Berezney -- Composition and structure of the internal nuclear matrix / Karin A. Mattern, Roel van Driel, and Luitzen de Jong -- High unwinding capability of matrix attachment regions and atc-sequence context-specific MAR-binding proteins / Terumi Kohwi-Shigematsu and Yoshinori Kohwi -- The Cyclin/cyclin-dependent kinase (cdk) complex: regulation of cell cycle progression and nuclear disassembly / R. Curtis Bird -- Nuclear architecture in developmental transciptional control of cell growth and tissue-specific genes / Gary S. Stein [and others] -- Transcription by RNA polymerase II and nuclear architecture / Derick G. Wansink, Luitzen de Jong, and Roel van Driel -- Protein deposition on nascent pre-mRNA transcripts / Sally A. Amero and Kenneth C. Sorensen.

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