NGF and related molecules in health and disease / edited by Luigi Aloe, Laura Calzà.
Series: Progress in brain research ; v. 146.Publisher: Amsterdam ; Boston : Elsevier, 2004Description: 1 online resource (xviii, 544 pages) : illustrations (some color)Content type:- text
- computer
- online resource
- 9780080497501
- 0080497500
- 0444514724
- 9780444514721
- Nerve growth factor and related molecules in health and disease
- Nerve growth factor -- Congresses
- Neurons -- Growth -- Congresses
- Neurotrophic functions -- Congresses
- Nervous system -- Diseases -- Molecular aspects -- Congresses
- Nervous system -- Diseases -- Treatment -- Research -- Congresses
- Nerve Growth Factor
- Nerve Growth Factors
- Facteur de croissance des nerfs -- Congrès
- MEDICAL -- Neuroscience
- PSYCHOLOGY -- Neuropsychology
- Groeifactoren (biowetenschappen)
- Zenuwstelsel
- Nerve growth factor
- Nervous system -- Diseases -- Molecular aspects
- Neurons -- Growth
- Neurotrophic functions
- QP376 .P7eb vol. 146
- W1
- WL 104
eBooks
The articles of this volume are part of scientific contributions presented at the 7th International Conference on NGF and related molecules, held in Modena, Italy, from 15 to 19 May 2002.
Includes bibliographical references and index.
I. Growth factors and cell signaling -- II. Growth factors, progenitor cells and cell survival -- III. Neurotrophins and CNS -- IV. Neurotrophins, PNS and peripheral tissues -- V. Neurotrophins and the immune system -- VI. Neurotrophins and neuro-inflammatory responses -- Neurotrophic factors and potential therapeutic applications -- VIII. Overview and conclusion.
The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.
Print version record.
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