Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed April 20, 2016).

Front Cover; Lessons in Immunity: From Single-Cell Organisms to Mammals; Lessons in Immunity: From Single-Cell Organisms to Mammals; Copyright; Contents; List of Contributors; Preface; 1 -- Ciliate Pheromones: Primordial Self-/Nonself-Recognition Signals; INTRODUCTION; PHEROMONE IDENTIFICATION; PHEROMONE STRUCTURES; PHEROMONE ACTIVITY; PHEROMONE STRUCTURE-FUNCTION RELATIONSHIPS WITH OTHER SIGNALING PROTEINS; CONCLUSIONS; REFERENCES; 2 -- Cell Death Pathways in an Unconventional Invertebrate Model; INTRODUCTION; SIGNALING PATHWAYS IN APOPTOTIC CELL DEATH OF THE IPLB-LDFB INSECT CELL LINE

AUTOPHAGY-MEDIATED CELL DEATH IN IPLB-LDFBCONCLUDING REMARKS; REFERENCES; 3 -- Immunotoxicology Approaches in Ecotoxicology: Lessons From Mollusks; MOLLUSK HEMOCYTES: TYPES AND FUNCTIONS; INTERACTION BETWEEN HEMOCYTES AND TOXICANTS: THE IMMUNOMARKER APPROACH; MOLLUSK IMMUNOMARKERS: THE ROLE OF CONFOUNDING FACTORS; REFERENCES; 4 -- New Aspects of Earthworm Innate Immunity: Novel Molecules and Old Proteins With Unexpected Functions; ESSENTIALS OF EARTHWORM IMMUNITY: A CONCISE INTRODUCTION; Earthworms as a Research Model in Life Sciences; Historical Foundation of Earthworm Immunity Research

Major Constituents of Earthworm Immune Response"STARS AND STRIPES" OR PATTERN RECOGNITION IN EARTHWORMS; Coelomic Cytolytic Factor: The Unique Earthworm Pattern Recognition Receptors; Variations on a Theme: Not Just Coelomic Cytolytic Factor Anymore; Toll-like Receptors Expression in Nonimmune Tissues; LYSENIN: A MULTITASKING PROTEIN IN EISENIA EARTHWORMS; Cellular Expression of Lysenin; Antimicrobial Induction of Lysenin; Inhibitors and Possible Regulators of Lysenin-Mediated Cell Lysis; LYSENIN MEETS NANOPARTICLES: UNEXPECTED RISE OF A NEW FUNCTION

Lysenin and the Concept of the Biomolecular CoronaThe High Affinity of Lysenin for Silver Nanoparticles; The Unexpected Role of Lysenin in the Accumulation of Nanoparticles; CONCLUSIONS AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; 5 -- Neuroprotection and Immunity in the Medicinal Leech Hirudo medicinalis: What About Microglia?; THE MEDICINAL LEECH CENTRAL NERVOUS SYSTEM; MICROGLIA AS BRAIN IMMUNE CELLS; IMMUNE RESPONSE AGAINST PATHOGENS; MICROGLIA RECRUITMENT; NEUROINFLAMMATORY MARKERS; TOWARD NERVE REPAIR: MICROGLIA/NEURONS CROSSTALK INTO THE SPOTLIGHT; CONCLUSIONS; REFERENCES

6 -- Specificity of Innate Immunity in Bivalves: A Lesson From BacteriaINNATE IMMUNITY IN BIVALVES: DIVERSITY AND COMPLEXITY; BIVALVES AND MARINE BACTERIA; IMMUNE RECOGNITION; IMMUNE SIGNALING; IMMUNE EFFECTORS; SPECIFICITY OF THE IMMUNE RESPONSE TO PATHOGENIC VIBRIOS: ROLE OF SURFACE INTERACTIONS AND SERUM-SOLUBLE COMPONENTS; CONCLUSIONS; REFERENCES; 7 -- Immune-Related Signaling in Mussel and Bivalves; PREMISE; MULTIPLE LAYERS OF BIOLOGICAL SIGNALING; IMMUNE SIGNALING AND RELATED CELL PROCESSES; HOW SMALL RNAS CAN INFLUENCE THE IMMUNE HOST RESPONSE; PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES

8 -- Crustacean Immunity: The Modulation of Stress Responses

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