Microbial Genomes -- Evolution and Origin of Virulence Isolates -- Genomic Approach to Understanding Infectious Disease Mechanisms -- Knockout and Disease Models in Toll-Like Receptor-Mediated Immunity -- Campylobacter -- Genomics of Helicobacter Species -- The Organization of Leptospira at a Genomic Level -- Listeria monocytogenes -- Mycobacterial Genomes -- Mycoplasma -- Genome Comparisons of Diverse Staphylococcus aureus Strains -- Type III Secretion Systems in Yersinia pestis and Yersinia pseudotuberculosis -- Genomics and the Evolution of Pathogenic Vibrio cholerae -- Future Directions of Infectious Disease Research.

The emergence and reemergence of infectious diseases, an increasing rate of antibiotic-resistant variants of pathogens, and the threat of bioterrorism underscore the importance of bacterial genomes and infectious diseases. Bacterial Genomes and Infectious Diseases presents major findings about bacterial genomes and their impact on strategy and approach for investigating mechanisms of pathogenesis of infectious diseases. This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria-host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria-host interactions, and diseases mechanisms.