Front Cover; Negative Affective States and Cognitive Impairments in Nicotine Dependence; Negative Affective States and Cognitive Impairments in Nicotine Dependence; Copyright; Dedication; Contents; List of Contributors; Preface; References; Acknowledgments; 1 -- Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical) ; INTRODUCTION; TOBACCO DEPENDENCE AND NICOTINE; THEORETICAL FRAMEWORK; POSITIVE REINFORCEMENT ASSOCIATED WITH NICOTINE USE; NEGATIVE REINFORCEMENT ASSOCIATED WITH NICOTINE USE; NEUROBIOLOGICAL MECHANISMS OF POSITIVE REINFORCEMENT.

NEUROBIOLOGICAL MECHANISMS OF NEGATIVE REINFORCEMENTTRANSLATIONAL ASPECTS OF THE NEUROBIOLOGY OF NEGATIVE REINFORCEMENT; References; 2 -- Nicotine Withdrawal and Attentional Deficit Studies Across Species: Conflation With Attentional Dysfunction in Psychiatric Patients ; NICOTINE USE, WITHDRAWAL, AND COGNITION; ATTENTIONAL DEFICITS RESULTING FROM NICOTINE WITHDRAWAL IN HUMANS; ATTENTIONAL DYSFUNCTION IN PSYCHIATRIC PATIENTS: OVERLAP WITH NICOTINIC RESEARCH; MECHANISMS UNDERLYING NICOTINIC EFFECTS ON ATTENTION; ATTENTIONAL DEFICITS FROM NICOTINE WITHDRAWAL IN ANIMALS.

IMPLICATIONS AND FUTURE STUDIESCONCLUSIONS; References; 3 -- Preclinical Models of Nicotine Withdrawal: Targeting Impaired Cognition ; INTRODUCTION; NICOTINE WITHDRAWAL IN LABORATORY RODENTS; NICOTINE EXPOSURE TO INDUCE PHYSICAL DEPENDENCE IN RODENTS; PHARMACOLOGICAL SCREENING; MEASURES OF COGNITION IN RODENT MODELS OF NICOTINE WITHDRAWAL; ANIMAL MODELS OF NICOTINE DEPENDENCE: WITHDRAWAL EFFECTS ON ATTENTION; PHARMACOLOGICAL TREATMENT OF NICOTINE DEPENDENCE; SUMMARY; References; 4 -- Genetic, Developmental, and Receptor-Level Influences on Nicotine Withdrawal-Associated Deficits in Learning.

INTRODUCTIONHIPPOCAMPUS-DEPENDENT LEARNING IS MORE SENSITIVE TO THE EFFECTS OF NICOTINE WITHDRAWAL THAN HIPPOCAMPUS-INDEPENDENT LEARNING; CHRONIC NICOTINE ACTS DIRECTLY IN THE HIPPOCAMPUS TO CHANGE NACHR FUNCTION AND DISRUPT LEARNING DURING WITHDRAWAL; GENETIC BACKGROUND MODULATES NICOTINE WITHDRAWAL EFFECTS ON LEARNING; EFFECTS OF NICOTINE WITHDRAWAL ON LEARNING VARY WITH AGE; CONCLUSION; References; 5 -- Enhanced Tobacco Use Vulnerability in Adolescents, Females, and Persons With Diabetes ; INTRODUCTION; NICOTINE REWARD AND WITHDRAWAL; ADOLESCENTS; FEMALES; PERSONS WITH DIABETES.

OTHER POPULATIONS TO CONSIDERCONCLUSION AND CLINICAL IMPLICATIONS; References; 6 -- Detrimental Effects of Prenatal Exposure to Tobacco Smoke and Nicotine ; INTRODUCTION; FUNCTIONAL ROLE OF NICOTINIC ACETYLCHOLINE RECEPTORS IN THE DEVELOPING NERVOUS SYSTEM; SOMATIC EFFECTS OF PRENATAL EXPOSURE TO TOBACCO SMOKE AND NICOTINE; Cardiovascular Outcomes; Metabolic Outcomes; Respiratory Outcomes; Fertility Outcomes; LONG-TERM NEUROBEHAVIORAL EFFECTS OF PRENATAL EXPOSURE TO TOBACCO SMOKE AND NICOTINE; Human Studies; Preclinical Studies; CONCLUSIONS; References.

7 -- Contribution of Translational Genetic Research to Our Understanding of Nicotine Dependence.

Includes bibliographical references and index.

Online resource; title from PDF title page (SpringerLink, viewed September 1, 2016).

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