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Network neuroscience / Flavio Frohlich.

By: Contributor(s): Publisher: London : Academic Press, [2016]Description: 1 online resource : illustratiosContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9780128015865
  • 0128015861
Subject(s): Genre/Form: Additional physical formats: Print version:: Network Neuroscience.LOC classification:
  • QP363.3
NLM classification:
  • 2017 A-963
  • WL 101
Online resources:
Contents:
Front Cover; NETWORK NEUROSCIENCE; NETWORK NEUROSCIENCE; Copyright; Dedication; Contents; Preface; Introduction; References; I -- NEURONS, SYNAPSES, AND CIRCUITS; 1 -- Membrane Voltage ; MEMBRANE VOLTAGE AND IONIC CURRENTS; MEASURING THE MEMBRANE VOLTAGE: CURRENT CLAMP; MEASURING IONIC CURRENTS: VOLTAGE CLAMP; DYNAMIC CLAMP; INSTRUMENTATION; Sharp Micropipette Intracellular Recordings; Whole-Cell Patch-Clamp Recordings; SUMMARY AND OUTLOOK; References; 2 -- Dynamics of the Action Potential; POTASSIUM CURRENT; SODIUM CURRENT; ACTION POTENTIALS; SUMMARY AND OUTLOOK; Reference
3 -- Synaptic TransmissionTHE CHEMICAL SYNAPSE; Presynaptic Voltage-Gated Calcium Channels; Presynaptic Calcium Dynamics; Postsynaptic Glutamate Receptors; Modeling Excitatory Synaptic Transmission; Metabotropic Glutamate Receptors; INHIBITORY SYNAPTIC TRANSMISSION; ELECTRICAL SYNAPSES; SUMMARY AND OUTLOOK; References; 4 -- Synaptic Plasticity; SHORT-TERM PLASTICITY; Short-Term Depression; Synaptic Facilitation; Modeling Short-Term Plasticity; LONG-TERM PLASTICITY; Mechanism of LTP and LTD; Spike-Timing-Dependent Plasticity; Modeling Long-Term Plasticity; SUMMARY AND OUTLOOK; References
5 -- NeuromodulatorsCORTICAL STATE; BASIC PRINCIPLES; ACETYLCHOLINE; Mechanisms; Behavior; DOPAMINE; Mechanisms; Behavior; NOREPINEPHRINE; Mechanisms; Behavior; HISTAMINE; Mechanisms; Behavior; SEROTONIN; Mechanisms; Behavior; MONOAMINE TRANSPORTERS; SUMMARY AND OUTLOOK; References; 6 -- Neuronal Communication Beyond Synapses; CHEMICAL SIGNALING BEYOND SYNAPSES; Neuropeptides; Nitric Oxide; EXTRACELLULAR ION CONCENTRATION DYNAMICS; ENDOGENOUS ELECTRIC FIELDS; SUMMARY AND OUTLOOK; References; 7 -- Microcircuits of the Neocortex; GLUTAMATERGIC CELLS; Pyramidal Cells; Spiny Stellate Cells
INHIBITORY INTERNEURONSBasket Cells; Other Types of Inhibitory Interneurons; THE CORTICAL MICROCIRCUIT; Layered Circuits of the Neocortex; Inhibitory Circuits; SUMMARY AND OUTLOOK; References; 8 -- Microcircuits of the Hippocampus; CIRCUIT LAYOUT OF THE HIPPOCAMPUS; DENTATE GYRUS; HIPPOCAMPAL FIELDS: CA1, CA2, AND CA3; CA1 Pyramidal Cells; CA3 Pyramidal Cells; SUBICULUM; ENTORHINAL CORTEX; FUNDAMENTAL LOCAL CIRCUIT PRINCIPLES; Excitatory Circuit Motifs; Inhibitory Circuit Motifs; SUMMARY AND OUTLOOK; NOTES; References; II -- MEASURING, PERTURBING, AND ANALYZING BRAIN NETWORKS; 9 -- Unit Activity
TERMINOLOGY AND CONCEPTSORIGIN OF THE EAP SIGNAL∗; RECORDING STRATEGIES; SPIKE SORTING; ANALYZING AND VISUALIZING UNIT ACTIVITY; SUMMARY AND OUTLOOK; References; 10 -- LFP and EEG; ELECTRIC FIELDS CAUSED BY NETWORK ACTIVITY; ELECTROENCEPHALOGRAM; LOCAL FIELD POTENTIAL; DATA ANALYSIS; SOURCE LOCALIZATION; INVASIVE RECORDING IN HUMANS; MAGNETOENCEPHALOGRAPHY; SUMMARY AND OUTLOOK; References; 11 -- Optical Measurements and Perturbations; CALCIUM IMAGING; Calcium Indicators; Calcium Imaging Setup; Applications; VOLTAGE-SENSITIVE DYE IMAGING; VSDI Setup; Applications; OPTOGENETICS
Summary: Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader's background. Dr. Flavio Frohlich (www.networkneuroscientist.org) wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab (www.frohlichlab.org) pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology.
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Includes bibliographical references and index.

Print version record.

Front Cover; NETWORK NEUROSCIENCE; NETWORK NEUROSCIENCE; Copyright; Dedication; Contents; Preface; Introduction; References; I -- NEURONS, SYNAPSES, AND CIRCUITS; 1 -- Membrane Voltage ; MEMBRANE VOLTAGE AND IONIC CURRENTS; MEASURING THE MEMBRANE VOLTAGE: CURRENT CLAMP; MEASURING IONIC CURRENTS: VOLTAGE CLAMP; DYNAMIC CLAMP; INSTRUMENTATION; Sharp Micropipette Intracellular Recordings; Whole-Cell Patch-Clamp Recordings; SUMMARY AND OUTLOOK; References; 2 -- Dynamics of the Action Potential; POTASSIUM CURRENT; SODIUM CURRENT; ACTION POTENTIALS; SUMMARY AND OUTLOOK; Reference

3 -- Synaptic TransmissionTHE CHEMICAL SYNAPSE; Presynaptic Voltage-Gated Calcium Channels; Presynaptic Calcium Dynamics; Postsynaptic Glutamate Receptors; Modeling Excitatory Synaptic Transmission; Metabotropic Glutamate Receptors; INHIBITORY SYNAPTIC TRANSMISSION; ELECTRICAL SYNAPSES; SUMMARY AND OUTLOOK; References; 4 -- Synaptic Plasticity; SHORT-TERM PLASTICITY; Short-Term Depression; Synaptic Facilitation; Modeling Short-Term Plasticity; LONG-TERM PLASTICITY; Mechanism of LTP and LTD; Spike-Timing-Dependent Plasticity; Modeling Long-Term Plasticity; SUMMARY AND OUTLOOK; References

5 -- NeuromodulatorsCORTICAL STATE; BASIC PRINCIPLES; ACETYLCHOLINE; Mechanisms; Behavior; DOPAMINE; Mechanisms; Behavior; NOREPINEPHRINE; Mechanisms; Behavior; HISTAMINE; Mechanisms; Behavior; SEROTONIN; Mechanisms; Behavior; MONOAMINE TRANSPORTERS; SUMMARY AND OUTLOOK; References; 6 -- Neuronal Communication Beyond Synapses; CHEMICAL SIGNALING BEYOND SYNAPSES; Neuropeptides; Nitric Oxide; EXTRACELLULAR ION CONCENTRATION DYNAMICS; ENDOGENOUS ELECTRIC FIELDS; SUMMARY AND OUTLOOK; References; 7 -- Microcircuits of the Neocortex; GLUTAMATERGIC CELLS; Pyramidal Cells; Spiny Stellate Cells

INHIBITORY INTERNEURONSBasket Cells; Other Types of Inhibitory Interneurons; THE CORTICAL MICROCIRCUIT; Layered Circuits of the Neocortex; Inhibitory Circuits; SUMMARY AND OUTLOOK; References; 8 -- Microcircuits of the Hippocampus; CIRCUIT LAYOUT OF THE HIPPOCAMPUS; DENTATE GYRUS; HIPPOCAMPAL FIELDS: CA1, CA2, AND CA3; CA1 Pyramidal Cells; CA3 Pyramidal Cells; SUBICULUM; ENTORHINAL CORTEX; FUNDAMENTAL LOCAL CIRCUIT PRINCIPLES; Excitatory Circuit Motifs; Inhibitory Circuit Motifs; SUMMARY AND OUTLOOK; NOTES; References; II -- MEASURING, PERTURBING, AND ANALYZING BRAIN NETWORKS; 9 -- Unit Activity

TERMINOLOGY AND CONCEPTSORIGIN OF THE EAP SIGNAL∗; RECORDING STRATEGIES; SPIKE SORTING; ANALYZING AND VISUALIZING UNIT ACTIVITY; SUMMARY AND OUTLOOK; References; 10 -- LFP and EEG; ELECTRIC FIELDS CAUSED BY NETWORK ACTIVITY; ELECTROENCEPHALOGRAM; LOCAL FIELD POTENTIAL; DATA ANALYSIS; SOURCE LOCALIZATION; INVASIVE RECORDING IN HUMANS; MAGNETOENCEPHALOGRAPHY; SUMMARY AND OUTLOOK; References; 11 -- Optical Measurements and Perturbations; CALCIUM IMAGING; Calcium Indicators; Calcium Imaging Setup; Applications; VOLTAGE-SENSITIVE DYE IMAGING; VSDI Setup; Applications; OPTOGENETICS

Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader's background. Dr. Flavio Frohlich (www.networkneuroscientist.org) wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab (www.frohlichlab.org) pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology.

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