Includes index.

Academic Press is an imprint of Elsevier.

Front Cover; Epigenetic Cancer Therapy; Copyright Page; Contents; List of Contributors; 1 Introduction; 1 Introduction to the Area (Key Concepts); 2 Epigenetics and Cancer; 3 Targeting Aberrant Epigenetics; 4 Issues to Overcome/Areas of Concern; 5 Future Directions: Translation to the Clinic; References; 1 Introduction and Key Concepts; 2 DNA Methylation and Hydroxymethylation in Cancer; 1 Introduction; 2 Epigenetics; 2.1 Chromatin Structure; 2.2 DNA Methylation in Cellular Homeostasis; 2.2.1 Genomic distribution of DNA methylation; 2.2.2 Functional role of DNA methylation.

2.2.3 DNA methyltransferases2.2.4 Recruitment of DNMTs; 2.3 DNA Demethylation; 3 DNA Methylation Patterns in Cancer; 3.1 Hypermethylation in Cancer; 3.2 Hypomethylation in Cancer; 3.3 Methods for 5mC Detection; 4 Aberrations of Enzymes Involved in DNA Methylation Homeostasis in Cancer; 4.1 DNA Methyltransferase; 4.2 TET Proteins; 4.3 Isocitrate Dehydrogenases; 4.4 Succinate Dehydrogenases; 5 DNA Hydroxymethylation in Cancer; 5.1 Methods for 5hmC Detection; 5.1.1 Affinity-based enrichment approach; 5.1.2 Chemical methods; 5.1.3 Quantitative methods at single base resolution.

5.1.4 Third-generation sequencing5.2 DNA Hydroxymethylation Patterns in Cancer; 6 Conclusion; References; 3 Writers, Readers, and Erasers of Epigenetic Marks; 1 Introduction; 2 Writers; 2.1 DNA Methyltransferases; 2.2 Histone Lysine Methyltransferases; 2.3 Protein Arginine Methyltransferases; 2.4 Histone Acetyltransferases; 3 Readers; 3.1 Methyl-CpG-Binding Proteins; 3.2 Histone Methylation-Binding Domains; 3.3 Histone Acetylation-Binding Domains; 4 Erasers; 4.1 Proteins Involved in DNA Demethylation; 4.2 Histone Demethylases; 4.3 Histone Deacetylases (HDACs).

5 Interactions between the Various Components6 Epigenetics and Cancer; 6.1 DNA Methylation and Cancer; 6.2 Histone Methylation and Cancer; 6.3 Histone Acetylation and Cancer; 7 Epigenetic Proteins as Therapeutic Targets; 8 Conclusion and Future Opportunities; References; 4 MicroRNAs and Cancer; 1 miRNA Biogenesis and Functionality; 2 miRNAs in Cancer Biology; 3 miRNA: An Epigenetic Perspective; 3.1 Epigenetic Alteration of miRNA Expression; 3.2 Epi-miRNA; 3.3 miRNA with Epigenetic Functions; 4 miRNA Epigenetic Therapy; 4.1 miRNA Inhibition in Cancer; 4.2 miRNA Replacement in Cancer.

4.3 Small-Molecule-Based miRNA Modulation5 Future Perspectives; Acknowledgments; References; 5 Long Noncoding RNAs and Cancer; 1 Introduction; 2 Classification and Nomenclature of lncRNAs; 2.1 Classification; 2.2 Nomenclature; 3 Mechanisms of lncRNA Function; 3.1 lncRNAs as Decoys and Guides; 3.2 lncRNAs as Scaffolds; 3.3 lncRNAs as Signaling Molecules; 3.4 miRNA Sequestration; 3.5 lncRNAs and Epigenetic Regulation; 3.5.1 H19; 3.5.2 AIR and KCNQ1OT1; 3.5.3 lincRNAs; 4 lncRNAs and Human Disease; 4.1 Prognostic Markers; 4.1.1 lncRNAs in the circulation.

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The bo.

Includes bibliographical references at the end of each chapters and index.

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