Streptococcus pneumoniae : molecular mechanisms of host-pathogen interactions / edited by Jeremy Brown, Sven Hammerschmidt, Carlos Orihuela.

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text

Media type:

computer

Carrier type:

online resource

ISBN:

9780124114531
0124114539

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Genre/Form:

Electronic books.

Additional physical formats: Print version:: Streptococcus Pneumoniae : Molecular Mechanisms of Host-Pathogen Interactions.LOC classification:

QR82.S78

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Contents:

Front Cover; Streptococcus pneumoniae; Copyright Page; Contents; List of Contributors; Preface; A. Streptococcus pneumoniae Epidemiology and Vaccines; 1 Molecular Epidemiology of Streptococcus pneumoniae; Etiological Diagnosis of Pneumococcal Infections; Some Basic Concepts in Molecular Epidemiology; Serotyping and Molecular Typing of S. pneumoniae; Serotyping; Pulsed-Field Gel Electrophoresis; Multilocus Sequence Typing; Other Typing Methods; Whole Genome Sequencing; Clones of S. pneumoniae; References; 2 Antibiotic Resistance of Pneumococci; Introduction; Risk Factors for Resistance.

Introduction of PCV Has Led to Direct and Indirect Protection Against Antimicrobial ResistanceConcluding Remarks; References; 3 Pneumococcal Vaccination and Consequences; Effect of the Vaccine on Pneumococcal Carriage; Effect of the Vaccine on the Disease; Impact of Conjugate Vaccines on Mucosal Infection; Effect of Conjugate Vaccines on IPD; Impact on Clinical Manifestations; Effect of PCV in Bacteremia and Meningitis; Effect of PCV in Pneumonia; Impact on Antimicrobial Resistance; Pneumococcal Conjugate Vaccination for Older Adults; Conclusion; References.

4 Vaccine Potential of Pneumococcal ProteinsIntroduction; Next-Generation Pneumococcal Vaccine Candidates and Strategies; Pneumolysin; Choline-Binding Proteins; Pneumococcal Surface Protein A; Pneumococcal Surface Protein C; Autolysin (LytA); Pneumococcal Choline-Binding Protein; Lipoproteins; Pneumococcal Surface Antigen A; PiuA and PiaA; Other Lipoprotein Vaccine Candidates; Pht Proteins; Sortase-Dependent Surface Proteins and Other Secreted Proteins; Recently Characterized Protein Vaccine Candidates; PcsB and StkP; AliA and GlpO; Whole Cell Vaccines; Conclusions and Future Perspectives.

Summary: Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases.

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eBooks

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Includes bibliographical references and index.

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Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases.

880-01 Introduction of PCV Has Led to Direct and Indirect Protection Against Antimicrobial ResistanceConcluding Remarks; References; 3 Pneumococcal Vaccination and Consequences; Effect of the Vaccine on Pneumococcal Carriage; Effect of the Vaccine on the Disease; Impact of Conjugate Vaccines on Mucosal Infection; Effect of Conjugate Vaccines on IPD; Impact on Clinical Manifestations; Effect of PCV in Bacteremia and Meningitis; Effect of PCV in Pneumonia; Impact on Antimicrobial Resistance; Pneumococcal Conjugate Vaccination for Older Adults; Conclusion; References.

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