Robustness of analytical chemical methods and pharmaceutical technological products / edited by Margriet M.W.B. Hendricks, Jan H. de Boer, Age K. Smilde.

Contributor(s):

text

Media type:

computer

Carrier type:

online resource

ISBN:

9780444897091
0444897097
9780080540634
0080540635

Subject(s):

Genre/Form:

Electronic books.

Additional physical formats: Print version:: Robustness of analytical chemical methods and pharmaceutical technological products.LOC classification:

RS189 .R576 1996eb

NLM classification:

1997 D-509
QV 744

Online resources:

Click here to access online

Contents:

General introduction to robustness / Age K. Smilde -- Stability and response surface methodology / Stephen P. Jones -- Review of the use of robustness and ruggedness in analytical chemistry / Y. Vander Heyden, D.L. Massart -- Robustness criteria. Incorporating robustness explicitly in optimization procedures utilizing multicriteria methods / Jan H. de Boer -- Ruggedness tests for analytical chemistry / Mary Mulholland -- Stabilizing a TLC separation illustrated by a mixture of several street drugs / C.A.A. Duineveld, P. Koopmans, P.M.J. Coenegracht -- Robustness of liquid-liquid extraction of drugs from biological samples / Jacob Wieling -- The use of a factorial design to evaluate the physical stability of tablets after storage under tropical conditions / C.E. Bos, G.K. Bolhuis, A.K. Smilde, J.H. de Boer.

Summary: In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given. Features of this book: & bull; Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry & bull; Illustrates the different approaches available to attain robustness & bull; Gives ideas on how to use methods in practical situations. The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.

Item type:

eBooks

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Includes bibliographical references and index.

In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given. Features of this book: & bull; Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry & bull; Illustrates the different approaches available to attain robustness & bull; Gives ideas on how to use methods in practical situations. The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.

Print version record.

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