Online resource; title from PDF title page (EBSCO, viewed October 31, 2016).

Includes index.

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Cover; Title Page; Copyright Page; Contents; Contributors; Preface; Chapter One -- Mouse Models of Gonadotrope Development; Abstract; 1 Introduction; 2 Signaling Pathways; 2.1 Fibroblast Growth Factors; 2.2 Bone Morphogenetic Proteins; 2.3 Notch; 2.4 Sonic Hedgehog; 2.5 ß-Catenin; 2.6 GnRH; 3 Transcription Factors; 3.1 PITX1 and PITX2; 3.2 LIM Homeodomain Factors; 3.3 GATA2 and POU1F1; 3.4 PROP1; 3.5 HESX1; 3.6 OTX1 and OTX2; 3.7 PAX6; 3.8 EGR1; 3.9 MSX1; 3.10 TBX19; 3.11 Orphan Nuclear Receptors; 3.12 Forkhead Box Transcription Factors.

3.13 Additional Genes Known to Contribute to Gonadotrope Development4 CRE Mice for Targeting Gonadotropes; 5 Concluding Remarks; References; Chapter Two -- Mouse Models for the Study of Synthesis, Secretion, and Action of Pituitary Gonadotropins ; Abstract; 1 Introduction; 2 a-Glycoprotein Hormone Subunit; 2.1 Cga Transgenic Mice; 2.2 Cga Knockout Mice; 2.3 Other Cga Models; 3 LHß Subunit; 3.1 Lhb Transgenic Mice; 3.1.1 LHß-CTP Transgenic Mice; 3.1.2 HCGß Transgenic Mice; 3.1.3 Ubiquitin c-hCGß Mice; 3.1.4 MT-hCGß Transgenic Mice; 3.2 Lhb Knockout Mice; 4 FSHß Subunit; 4.1 Fshb Transgenic Mice.

4.1.1 Gonadotrope-Targeted HFSHB Transgenic Mice4.1.2 MT-hFSHß Transgenic Mice; 4.1.3 Igf1-hFSHß Transgenic Mice; 4.2 Fshb Knockout Mice; 4.3 Genetic Rescue of Fshb Null Mice; 4.4 FSH Rerouted Mice; 4.5 FSH Glycosylation Mutant Mice; 5 Transforming Growth Factor-ß Superfamily Members and Gonadotropins; 5.1 Inhibins and Activins; 5.2 Inha Knockout Mice; 5.3 Inha/Gonadotropin Double Knockout Mice; 5.4 Knockout Mice for Activin Ligands; 5.5 Activin Receptor2A Knockout Mice; 5.6 Knockout Mice for Smads; 5.7 Gdf9 Knockout Mice; 5.8 Follistatin Transgenic Mice; 5.9 Follistatin Knockout Mice.

6 Other Mouse Models7 Conclusions and Future Directions; Acknowledgments; References; Chapter Three -- Clinical Applications of Gonadotropins in the Female: Assisted Reproduction and Beyond; Abstract; 1 Introduction; 2 Molecular Biology of the Ovarian Response; 2.1 Concepts From Evolution and Population Genetics in Females; 2.2 Modulation of FSH Action by FSHR Variants In Vitro; 2.3 Differentiating LH and hCG Action In Vitro; 3 Gonadotropins in Assisted Reproduction; 3.1 Urinary Gonadotropin Preparations; 3.2 Recombinant Gonadotropin Preparations; 3.3 Biosimilar Gonadotropins.

3.4 Do Different Preparations Have Different Clinical Effects?4 Ovarian Stimulation Protocols in ART; 4.1 Classic Scheme(s) of Gonadotropin Stimulation in ART; 4.2 ART in Poor Responder Women; 4.3 ART in Women With Polycystic Ovarian Syndrome; 5 Adverse Events in Ovarian Stimulation; 5.1 Ovarian Hyperstimulation Syndrome; 5.2 Premature Ovarian Failure; 5.3 Other Complications; 6 Gonadotropins Beyond ART; 6.1 Gonadotropins and Thyroid Axis; 6.2 Gonadotropins and Insulin-Like Growth Factors; 6.3 Molecular Basis of Hormone Interactions; 6.4 Gonadotropins and Cancer; 7 Conclusions.

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