Online resource; title from PDF title page (EBSCO, viewed October 27, 2017).

Includes bibliographical references and index.

"Approaches to Understanding Breast Cancer, Volume 151, the latest volume in the Progress in Molecular Biology and Translational Science series focuses on breast cancer, with new chapters that include information on Breast Cancer Epidemiology, Prevention, and Screening, DCIS: Current Principles of Management, Pregnancy and Hormonal Prevention of Breast Cancer, Chemokines: Key Players in Pathobiology of Breast Cancer, Mircrobiota and Breast Cancer, Experimental Therapeutic Use of Estrogen Receptor Beta Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations from Pre-Clinical Models, Targeting Breast Cancer Stem Cells: Key for Anti-Metastatic Therapy, and Experimental Therapy of Advanced Breast Cancer: Target NFAT1-MDM2-p53 Pathway. Accessible to students and researchers alikeWritten by leading authorities in the field"-- Provided by publisher.

""Cover""; ""Title page ""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""Chapter One -- Breast Cancer Epidemiology, Prevention, and Screening""; ""Abstract""; ""1 Introduction""; ""2 Breast cancer epidemiology""; ""2.1 Trends Over Time""; ""3 Risk factors for breast cancer""; ""3.1 Nongenetic, Nonmodifiable Risk Factors""; ""3.1.1 Age""; ""3.1.2 Race""; ""3.1.3 Early Menarche/Late Menopause""; ""3.1.4 Breast Characteristics""; ""3.2 Nongenetic, Modifiable Risk Factors""; ""3.2.1 Income, Education, and Insurance Status""; ""3.2.2 Changing Reproductive Patterns""

""3.2.3 Menopausal Hormone Use""""3.2.4 Tobacco""; ""3.2.5 Alcohol""; ""3.2.6 Fitness and Nutrition""; ""3.3 Genetic Risk Factors""; ""3.3.1 BRCA1 and BRCA 2 Mutations""; ""3.3.2 BRCA Mutation Screening""; ""4 Breast cancer prevention""; ""4.1 Lifestyle/Behavior Change Interventions""; ""4.2 Chemoprevention""; ""4.3 Surgery""; ""5 Breast cancer early detection and screening""; ""5.1 History of Screening""; ""5.2 Screening Benefits and Harms""; ""5.3 Screening Recommendations""; ""5.4 Breast Cancer Screening in Average Risk Women""

""5.5 Genetic Mutations, Breast Cancer Screening Tools, and Screening Methods in High-Risk Women""""5.6 Screening Modalities""; ""5.7 Breast Ultrasound""; ""References""; ""Chapter Two -- Current Approaches to Diagnosis and Treatment of Ductal Carcinoma In Situ and Future Directions""; ""Abstract""; ""1 Introduction and background""; ""2 Epidemiology""; ""3 Natural history""; ""4 Diagnosis""; ""5 Imaging""; ""5.1 Mammography""; ""5.2 Ultrasonography""; ""5.3 MRI""; ""6 Biopsy""; ""7 Histologic classification""; ""8 Treatment""; ""8.1 Mastectomy""; ""8.2 BCT""; ""8.3 Margin Status""

""8.4 Sentinel Lymph Node Biopsy""""9 Adjuvant therapy""; ""9.1 Role of Radiation""; ""9.2 Rationale for Considering Not Undergoing Adjuvant Radiation""; ""9.3 Chemotherapy""; ""10 Significance of biologic markers/molecular features-future directions in possible prognostic indicators""; ""10.1 p53""; ""10.2 Hormone Receptors""; ""10.3 EGFR""; ""10.4 HER2""; ""10.5 Bcl-2""; ""11 Breast cancer stem cells""; ""References""; ""Chapter Three -- Pregnancy and Breast Cancer""; ""Abstract""; ""1 Introduction""; ""2 Development of the Mammary Gland""; ""3 Types of Breast Cancer""

""4 Stages of Breast Cancer""""5 Risk Factors""; ""5.1 Age and Gender""; ""5.2 Geographical Location""; ""5.3 Personal and Family History""; ""5.4 Heredity""; ""5.5 Breast Lesions""; ""5.6 Race""; ""5.7 Weight""; ""5.8 Alcohol""; ""5.9 Radiation""; ""5.10 Hormone Replacement Therapy""; ""5.11 Reproductive History""; ""5.12 Breastfeeding""; ""6 Early Full-Term Pregnancy and Breast Cancer""; ""7 Potential Mechanisms of Early Full-Term Pregnancy-Induced Protection Against Breast Cancer""; ""7.1 Altered Systemic Hormonal Environment and Hormone Responsiveness""

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