Naturally Occurring IgM Antibodies to Oxidation‑Specific Epitopes -- Naturally Occurring Autoantibodies to Apoptotic Cells -- Naturally Occurring Antibodies Directed against Carbohydrate Tumor Antigens -- Naturally Occurring Antibodies as Therapeutics for Neurologic Disease: Can Human Monoclonal IgMs Replace the Limited Resource IVIG? -- Nature and Nurture of Catalytic Antibodies -- Naturally Occurring Autoantibodies in Mediating Clearance of Senescent Red Blood Cells -- Naturally Occurring Autoantibodies against b‑Amyloid -- Multi‑Faceted Role of Naturally Occurring Autoantibodies in Fighting Pathogens -- Immunoregulation by Naturally Occurring and Disease‑Associated Autoantibodies: Binding to Cytokines and their Role in Regulation of T‑Cell Responses -- Modulation of Dendritic Cells and Regulatory T Cells by Naturally Occurring Antibodies -- Control of B Cells Expressing Naturally Occurring Autoantibodies -- Granulocyte Death Regulation by Naturally Occurring Autoantibodies -- Naturally Occurring Autoantibodies Mediate Ischemia/Reperfusion‑Induced Tissue Injury -- How Immune Complexes from Certain IgG NAbs and any F(ab’)2 can Mediate Excessive Complement Activation -- The Natural Autoantibody Repertoire in Newborns and Adults: A Current Overview -- Antibody Polyspecificity: What Does It Matter? -- Positive and Negative Selection of Natural Autoreactive B Cells -- Naturally Occurring Antibodies/Autoantibodies in Polyclonal Immunoglobulin Concentrates.

This volume illustrates the functional properties of NAbs. Authors from pioneering groups report in their chapters on the tissue homeostatic, tissue regenerating and regulatory properties of NAbs and NAbs in pooled human IgG. Scientists interested in the regulation and modulation of components of the immune system found a whole variety of NAbs to cytokines with regulatory and protective functions and NAbs that modulate, e.g., dendritic cells, regulatory T cells, B cells and granulocytes. Considering the large plasma pools and initial difficulties in preparing IVIG that does not induce adverse effects upon infusion into recipients, this volume ends with a historical chapter on how pooled human plasma was fractionated and the IgG component pretreated for a safe intravenous application.