Includes bibliographical references and index.

Overview of drug transporter families -- Organic Cation and Zwitterion transporters OCT, OCTN -- Organic anion transporters OAT -- Organic anion transporting polypeptides OATP -- Mammalian peptide transporters PEPT -- The monocarboxylate transporters MCT -- The nucleoside transporters CNT, ENT -- Bile acid transporters -- Multidrug resistance protein P-glycoprotein -- Multidrug resistance-associated proteins MRP -- Breast cancer resistance protein BCRP -- Multidrug and toxin extrusion proteins MATE -- Drug transport in the liver -- Drug transport in the brain -- Drug transport in the kidney -- Drug transport in the intestine -- Drug transport in the placenta -- Experimental approaches to studying drug transport -- Transporters in drug discovery in silico approaches -- Polymorphisms of drug transporters and clinical relevance -- Diet/nutrient interactions with drug transporters -- Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity -- Regulatory science perspectives on transporter studies in drug development.

John Wiley and Sons Wiley eBooks