Endodontics is a branch of dentistry that deals with the tooth pulp and its diseases. It is gaining importance due to patients’ increasing awareness of dental health, prevention, saving teeth and oral hygiene. There is a demand for a painless alternative to extraction to save the teeth and this alternative is root canal therapy. The 21st-century endodontics with all its advancements is on the way to solve the existing numerous difficulties. The ultimate goal of modern endodontics is to effectively shape the root canals to facilitate thorough cleaning of entire system with less time consumption leading to easy and effective obturation. Advanced Endodontics is meant mainly for postgraduate students. It includes the most recent developments in the field of endodontics. From diagnosis to Periapical surgery, there have been significant changes, both in concept and equipment. Recently, tissue engineering has been used to revitalize dentin and pulp tissue. Endodontics is growing with rapidly changing treatment modalities in accordance with advancements in the technology leading to the precision in treatment outcome. No other branch in dentistry is changing at this rate. Procedures from access cavity preparation, Microscopes, Apex locators, Rotary instrument systems, Obturating systems and surgical endodontics to tissue engineering have changed to an extent to appreciate the results clinically. The book in the form of Advanced Endodontics is the contribution of my vast experience to the profession.