This volume includes paradigms, model systems, and techniques for the study of dysfunctions in the nervous system. The advantages and disadvantages of the approaches presented are critically discussed. Key Features * Neural injury * Developmental cell death * Disease processes and aging.

Paradigms for Study of Neurotrophin Effects in Oxidant Injury, G.R. Jackson and J.R. Perez-Polo. -- Nitric Oxide Toxicity in Central Nervous System Cultures, V.L. Dawson and T.M. Dawson. -- Development of in Vitro Injury Models for Oligodendroglia, A. Espinosa, P. Zhao, and J. de Vellis. -- Glia Models to Study Glial Cell Cytotoxicity, A. Vernadakis and M.S. Kentroti. -- Rodent Glioma Models, W.W. Maggio. -- Peripheral Lesioning of Olfacory System: Expression of Neurotrophin Receptors, C.P. Turner and J.R. Perez-Polo. -- Basal Forebrain Cholinergic Lesions and Complete Transection of Septal-Hippocampal Pathway, L.R. Williams. -- Neurochemical Lesions: Tools for Functional Assessment of Serotonin Neuronal Systems, J.M. Lakoski, B.J. Keck, and A. Dugar. -- Cerebral Glucose/Energy Metabolism: Valid Techniques in Humans and Animals, S. Hoyer. -- Heavy Metal Effects on Glia, E. Tiffany-Castiglioni, M.E. Legare, L.A. Schneider, E.D. Harris, R. Barhoumi, J. Zmudzki, Y. Qian, and R.C. Burghardt. -- Source, Metabolism, and Function of Cysteine and Glutathione in the Central Nervous System, D.K. Rassin. -- Magnetic Resonance Spectroscopy of Neural Tissue, R.J. McClure, K. Panchaligam, W.E. Klunk, and J.W. Pettegrew. -- Acute Stroke Diagnosis with Magnetic Resonance Imaging, S.C. Jones, N.C. Huang, M.J. Quast, A.D. Perez-Trepechio, G.R. Hillman, and T.A. Kent. -- Evaluation of Free Radical-Initiated Oxidant Events within the Nervous System, S.C. Bondy. -- Exogenous Administration of Cytokines into the Central Nervous System: Analysis of Alterations in Cell Morphology and Molecular Expression, M.A. Kahn and J. de Vellis. -- Animal Models to Produce Cortical Cholinergic Dysfunction, R. Schliebs and V. Bigl. -- In Vitro Studies of Liposome-Mediated Gene Transfection, K. Yang, J.R. Perez-Polo, F. Faustinella, G. Taglialatela, and R.L. Hayes. -- Construction and Analysis of Transgenic Mice Expressing Amyloidogenic Fragments of Alzheimer Amyloid Protein Precursor, R.L. Neve and F.M. Boyce. -- Golgi Technique Used to Study Stress and Glucocorticoid Effects on Hippocampal Neuronal Morphology, A.M. Magarinos, E. Fuchs, G. Flügge, and B.S. McEwin. -- Index.

Includes bibliographical references and index.

Print version record.

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